ID H2LZN5_ORYLA Unreviewed; 721 AA.
AC H2LZN5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA-binding protein RFX2 {ECO:0000256|ARBA:ARBA00039910};
DE AltName: Full=Regulatory factor X 2 {ECO:0000256|ARBA:ARBA00042136};
GN Name=rfx2 {ECO:0000313|Ensembl:ENSORLP00000011608.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011608.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011608.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011608.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011608.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011608.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2LZN5; -.
DR Ensembl; ENSORLT00000011609.2; ENSORLP00000011608.2; ENSORLG00000009257.2.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR HOGENOM; CLU_010393_1_1_1; -.
DR TreeFam; TF321340; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000009257; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF17; DNA-BINDING PROTEIN RFX2; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 209..284
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 688..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 80053 MW; 144620E18300922A CRC64;
MQNAEGGSDT TTTVAALRTS SSAQAPVVQP VPASQQRVLV QAVGSAQKGG QVQQISVPRV
QQVPQQVQQV QHVYPSQVQY VGEGGEAVYT NGTIRTAYSY NPESQLYGQN SGGTYFDSQA
GGAHVTTVVS SASGGVPPHG MVGIAMEVGS GHIISSGSPY LIHGGSMEGS RNHISHSSRS
SSAMLEMAIE NLQKSEGIAS HKSSLLNSHL QWLLDNYETA EGVSLPRCSL YNHYLRHCQE
QKLDPVNAAS FGKLIRSVFM GLRTRRLGTR GNSKYHYYGI RVKPDSPLNR LQEDTQYMAM
RQQPVHQKQR FKPLQKVDSM SDSLCGSSQA CNSTPEQSVA AQSQHHQHYI DTSHTLPQFP
PLDVGSQPLP ERINMGDIKK LKTLYRDHCE ATLDVVMNLQ FHYIEKLWQT FWCSTAPSSD
GSTSIPSSDD DMEGSIPREK LVALCKYEPV RLWMRSCDHI LYQALVEVLI PDVLRPVPST
LTQAIRNFAK SLEGWLTNAM TSFPQEIVRT KVAVVSAFAQ TLRRYTSLNH LAQAARAVLQ
NTSQINQMLS DLNRVDFANV QEQASWVCQC DESVVQRLEQ DFKVTLQQQS SLDQWATWLD
NVVSQVLKPH QGNPSFPKAA RQFLLKWSFY SSMVIRDLTL RSAASFGSFH LIRLLYDEYM
FYLVEHRVAQ ATGETPIAVM GEVNASDEMS GMGSDADASR EISEPSVKRE RIEMSQSLQE
M
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