ID H2LZR6_ORYLA Unreviewed; 410 AA.
AC H2LZR6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=WD repeat and FYVE domain containing 1 {ECO:0000313|Ensembl:ENSORLP00000011639.2};
GN Name=wdfy1 {ECO:0000313|Ensembl:ENSORLP00000011639.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011639.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011639.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011639.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011639.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011639.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR RefSeq; XP_004075764.1; XM_004075716.2.
DR AlphaFoldDB; H2LZR6; -.
DR STRING; 8090.ENSORLP00000011639; -.
DR Ensembl; ENSORLT00000011640.2; ENSORLP00000011639.2; ENSORLG00000009280.2.
DR GeneID; 101158125; -.
DR KEGG; ola:101158125; -.
DR CTD; 57590; -.
DR eggNOG; KOG1409; Eukaryota.
DR GeneTree; ENSGT00940000157731; -.
DR HOGENOM; CLU_046919_0_0_1; -.
DR InParanoid; H2LZR6; -.
DR OMA; IFCLGAE; -.
DR OrthoDB; 5385125at2759; -.
DR TreeFam; TF314470; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000009280; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IBA:GO_Central.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; LD41958P; 1.
DR PANTHER; PTHR46189:SF2; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT REPEAT 20..51
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 195..228
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 238..279
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 281..352
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REPEAT 362..395
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 410 AA; 46447 MW; E8D3816E96841C24 CRC64;
MAAEIHSRPQ TARPVLLNKI EGHTDAVNAA VLIPKEDGVI TVSEDRTIRV WLKRDSGQYW
PSIYHTVSSP CSCMSYHHDS RRIFIGQDNG SVVEFLISED FNKMNHVKTY PAHQNRVSAL
VFSLESEWLV STGHDKSLSW MCTQSGSMLG RHCFSTWASC LQYDHETQHA FVGDFSGQVT
MLKLERQTYS IVTTLKGHEG SVGALWWDPV QRLLFSGASD HSVIMWDIGG RKGRTLLLQG
HHERVQAIRY LQLTRQLISC SADGGVAVWN MDTQREEAPQ WLDSDSCQKC EQPFFWNIKQ
MWDTKTLGLR QHHCRKCGKA VCGKCSSKRS TFPIMGFEFP VRVCDDCFAI IKDEDRTPLA
TFHEGKHNIA HMDMDPSRGL MVTCGSDRIV KIWDMTQVVG CSLATGFSQR
//
