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Database: UniProt
Entry: H2M0N6_ORYLA
LinkDB: H2M0N6_ORYLA
Original site: H2M0N6_ORYLA 
ID   H2M0N6_ORYLA            Unreviewed;       584 AA.
AC   H2M0N6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-JUN-2018, entry version 44.
DE   RecName: Full=Translation factor GUF1, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03137};
DE            EC=3.6.5.n1 {ECO:0000256|HAMAP-Rule:MF_03137};
DE   AltName: Full=Elongation factor 4 homolog {ECO:0000256|HAMAP-Rule:MF_03137};
DE            Short=EF-4 {ECO:0000256|HAMAP-Rule:MF_03137};
DE   AltName: Full=GTPase GUF1 {ECO:0000256|HAMAP-Rule:MF_03137};
DE   AltName: Full=Ribosomal back-translocase {ECO:0000256|HAMAP-Rule:MF_03137};
GN   Name=GUF1 {ECO:0000256|HAMAP-Rule:MF_03137};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011962, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000011962, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011962,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000011962}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011962};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Promotes mitochondrial protein synthesis. May act as a
CC       fidelity factor of the translation reaction, by catalyzing a one-
CC       codon backward translocation of tRNAs on improperly translocated
CC       ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent
CC       manner. {ECO:0000256|HAMAP-Rule:MF_03137}.
CC   -!- CATALYTIC ACTIVITY: GTP + H(2)O = GDP + phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_03137}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|HAMAP-Rule:MF_03137}; Peripheral membrane protein
CC       {ECO:0000256|HAMAP-Rule:MF_03137}; Matrix side {ECO:0000256|HAMAP-
CC       Rule:MF_03137}.
CC   -!- SIMILARITY: Belongs to the GTP-binding elongation factor family.
CC       LepA subfamily. {ECO:0000256|HAMAP-Rule:MF_03137}.
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DR   EMBL; BAAF04054814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSORLT00000011963; ENSORLP00000011962; ENSORLG00000009541.
DR   GeneTree; ENSGT00550000074940; -.
DR   Proteomes; UP000001038; Chromosome 10.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03709; lepA_C; 1.
DR   Gene3D; 3.30.70.2570; -; 1.
DR   HAMAP; MF_00071; LepA; 1.
DR   InterPro; IPR006297; EF-4.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR038363; LepA_C_sf.
DR   InterPro; IPR013842; LepA_CTD.
DR   InterPro; IPR035654; LepA_IV.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF06421; LepA_C; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03137};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT   DOMAIN       30    211       Tr-type G. {ECO:0000259|PROSITE:PS51722}.
FT   NP_BIND      39     46       GTP. {ECO:0000256|HAMAP-Rule:MF_03137}.
FT   NP_BIND     104    108       GTP. {ECO:0000256|HAMAP-Rule:MF_03137}.
FT   NP_BIND     158    161       GTP. {ECO:0000256|HAMAP-Rule:MF_03137}.
SQ   SEQUENCE   584 AA;  65240 MW;  EC9C424240A81F68 CRC64;
     MSGFPSITFR RRTSTQADKD TVDLSKFPAD RIRNFCIVAH IDHGKSTLAD RLLEMTGAIA
     KTGKNKQVLD KLQVERERGI TVKAQTASLF YDYGGEQYLL NLIDTPGHVD FSYEVSRSLS
     ACQGVLLIVD ANQGIQAQTV ANFYLAFEAQ LSIIPVINKI DLKNADPSRV ESQIEKVFDI
     PSEECIRISA KLGTNVEKVL QAVVERIPAP AGSVHEPFKA LVFDSNFDHY RGVVANIAVL
     GGRVKKGDKI VSAHLRKTYE VNELGLLRPD ELPTQKLFAG QVGYIIAGMK EVKEAQIGDT
     LFLQERPVDA LPGFKPAKPM VFAGMYPMDQ SEYPGLRSAI ERLTLNDSSV MVQRDSSLAL
     GAGWRLGFLG LLHMEVFNQR LEQEYNASVI VTAPTVPYKA VLSSAKLIKN RRGVQKNMVY
     IDDQRVMMKY LFPLNEIVVD FYDLLKSLSS GYASFDYESA GYQAADLIKM DLLLNGHPVE
     ELTTIVHRER AYTMGKAMCE RLKDSIPRQM FEIAVQAAIG SKVIARETIK AYRKNVLAKC
     YGGDITRKMK LLKKQAEGKK KMRRIGNVDV PKDAFINVLK RKDK
//
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