ID H2M0Y7_ORYLA Unreviewed; 659 AA.
AC H2M0Y7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Growth arrest-specific 2 like 3 {ECO:0000313|Ensembl:ENSORLP00000012065.2};
GN Name=gas2l3 {ECO:0000313|Ensembl:ENSORLP00000012065.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012065.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012065.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012065.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012065.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012065.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAS2 family.
CC {ECO:0000256|ARBA:ARBA00038441}.
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DR STRING; 8090.ENSORLP00000036803; -.
DR Ensembl; ENSORLT00000012066.2; ENSORLP00000012065.2; ENSORLG00000009624.2.
DR Ensembl; ENSORLT00000038268.1; ENSORLP00000036803.1; ENSORLG00000009624.2.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000159389; -.
DR HOGENOM; CLU_025484_1_1_1; -.
DR OrthoDB; 1361287at2759; -.
DR TreeFam; TF323754; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000009624; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0008093; F:cytoskeletal anchor activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0051764; P:actin crosslink formation; IBA:GO_Central.
DR GO; GO:0021923; P:cell proliferation in hindbrain ventricular zone; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR PANTHER; PTHR46756:SF7; GAS2-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR46756; TRANSGELIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF02187; GAS2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00243; GAS2; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51460; GAR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 56..177
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 218..290
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 304..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..481
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 70943 MW; 08F002E5CAE6B091 CRC64;
MAVQGGIQVW HGEKFDAPLL SPRSPRGLLG QRHGPGLTDV FQYDQWLAVR HEATLVPMQE
DLAIWLSSLL GEEVRAEFFM EELNNGVRLC QLIGVLQAKV NQNGPPERSK LFPTKTVACK
RDASPGSFFA RDNTANFLAW CRRIGVEETY LFESEGLVLH KDPRQVCLCL LEIGRIVSKY
GVEPPVLVKL EKEIEMEETR LLAEEPPPAV KTFSVCCQHG GLYHPGEPDP DEPPCSCSNR
VSIEYLSEGR YRLGDKTIFI RMLHGKHVMV RVGGGWDTLR GFLSKYDPLR VLQFTTLEQK
ILAFQKGPPG PRGPPSSVAP PPDMDPLAAV DDLVSSSSSA SSSSSSSSSG SACKHPPPAY
TCRSCTPSPA CTPTLPRRGP APKKTVQTTP SSSPRKPTML PLPVTTKSPA PSPSASVGSS
PCLGRRGVQV QLRAATPTGH PAGTSPAPKG KLRTQGPASK PRSPVCPEPS SKCPKPSSPC
ATPVPRSLAT TAPPSRDARP PTGANQRSRL AQRRSGSPAS RLRLEAVRRA RMATRAAAAP
QSRTPSPSSR TASPTPPKPA SAPPKGTVGP AKTRLQMPNK GNAPRVVPGA NTGIRANQKA
PTTTKEAGQR PEMTAGSKAT VKPERTDGVE QRTATKKPPL CSKREEPYFE MNCRRKQWA
//
