ID   H2M2I8_ORYLA            Unreviewed;       699 AA.
AC   H2M2I8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN   Name=LOC101168224 {ECO:0000313|Ensembl:ENSORLP00000012632.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012632.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000012632.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012632.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000012632.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012632.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   AlphaFoldDB; H2M2I8; -.
DR   Ensembl; ENSORLT00000012633.2; ENSORLP00000012632.2; ENSORLG00000010069.2.
DR   eggNOG; KOG2237; Eukaryota.
DR   GeneTree; ENSGT00530000063426; -.
DR   HOGENOM; CLU_011290_1_1_1; -.
DR   TreeFam; TF300655; -.
DR   Proteomes; UP000001038; Chromosome 11.
DR   Bgee; ENSORLG00000010069; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF4; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368024};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          4..411
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          480..694
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   699 AA;  78918 MW;  D0AAA15EE1DAEB02 CRC64;
     MTKKVDDYHG TQICDSYAWL EDPDGAETKA FVEAQNKLTM PYLEGCAVRP QFHKRLTELY
     DHPKYSCPYK RGTRYFYFHN EGLQNQDVLY VQGALDAPAT VFFDPNKLSD DGTVALKMGR
     LSEDCQYFAY GLSSSGSDWV TVHFMRADDL TKLPDVLDRV KFSCLAWTHD AKGIFYNSYP
     RQDGKTDGTE TTTNINQKLY YHVIGTEQSA DVLVAEFPDH PKWHSSVTIS DDGRYAVLSI
     TEGCEPVNQL WYCDLQQLPD GIKGLLPWVK LVDNFEAQYS YITNEGSVFS FRSNLDAPRY
     RLINIDIQNP DRQHWTTLIP QHDKDVLGFV SCVNQRHLLV NYVHDVKDIL QLYELSSGRL
     IRDLPLDVGT VAGVSCKKKH SDFFYKFTSF TTPGIIYHCD LSEPNPEPKV FREVEVKGIK
     QEDFQTTQVF YPSKDGTSIP MFLVHSKDLK RDGTNPVFLY GYGGFEASIQ PYYNVAYLLF
     VRHLGGILAV ANIRGGGEYG LTWHKAGTLE NKQNCFDDFQ CAAEYLIKEK YTTASRLAIN
     GASNGGLLVA ACMIQRPDLF GCVVAEVGVM DMLKFHKFTI GHAWTTDYGC SDDSKQFQWL
     IKYSPLHNLP PPPYTGPPYP AVLLLTADHD DRVVPLHTLK FCAALQHGVG SSPQQKQPLM
     VRVDTRSGHG AGKPTTKAIL EETHIFSFIA ETLGISWKD
//