ID H2M2K8_ORYLA Unreviewed; 1267 AA.
AC H2M2K8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Protocadherin 1 {ECO:0000313|Ensembl:ENSORLP00000012653.2};
GN Name=PCDH1 {ECO:0000313|Ensembl:ENSORLP00000012653.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012653.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012653.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012653.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012653.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012653.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2M2K8; -.
DR Ensembl; ENSORLT00000012654.2; ENSORLP00000012653.2; ENSORLG00000010092.2.
DR eggNOG; ENOG502QWB7; Eukaryota.
DR GeneTree; ENSGT00940000155521; -.
DR HOGENOM; CLU_006480_5_3_1; -.
DR InParanoid; H2M2K8; -.
DR TreeFam; TF320624; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000010092; Expressed in sexually immature organism and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF247; PROTOCADHERIN-1; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 894..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..209
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 210..321
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 322..428
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 437..547
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 548..653
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 654..756
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 777..876
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 925..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1165..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 137892 MW; C95ECA37B971066D CRC64;
MNEISVFNPC DILGTLTLGV GSSRPVVPNL FVTADRYNAR HVYHGPVGDG GLRCNARCVS
REVWCRDFGV RRSSDDLMEL NSRVLLLLVV LLHCGPAKGS ILYRVQEEQP PNTLIGSLAA
DHGLPDSGHL YKLEVGAPYL RVDGKTGDIF TTEIPIDRET LRDCRSLVKG KPCYLEFEVS
VTDLLQNPSP RLIEGRIEVQ DINDNTPQFP LSVLTISVPE NTIMGALFSI PLATDRDSER
NGVADYALTA GPDAATLFGL QVADDRGGKL PQLIVLGNLD RELKDSYDLT IKAVDGGNPQ
RYSQALLRVV VTDANDNSPK FEHPSYEAEV SENSPVGHSV LQVKADDSDM GPNGEIEYSL
HQAVDPVPKL LRIDRTTGII YVKGPLDREE INSLSFYVVA RDKGPQPKSS KTFVTIEVTD
QNDNAPAVEI RGIGLVTHSE GIANISEDMP VGTAVALVQV SDKDEGENAV VTCVVAGDVP
FQLRPASDST SDNKRKYFLQ TTTPLDYERV KEYRVEIVAV DSGNPALSST NSLKVQVTDV
NDNSPVFSPT IFEVDFAEEN QPGETILDVT ATDADSGTNA ELFYNIVGDS YIKGLFEIDP
NTGEVKARTP LDREHKERYE FRVTAADKGS PVHKGTATVV IKVLDCNDND PKFMLSGYSF
SVLENMPPLS PVGMVTVLDM DKGENAHVHL SVEPDGGKFV VQNGTGTILS SISFDREKES
SYTFRLKAVD GGEPPRSSYV GVTINVLDEN DNDPVVTKPS NSSFRQLSPV ASPDSHVDVV
EAEDLDSGPN ADLVFSIAGG NPYQLFRISP SSGEITLAKE MTRKHGGLHR LVVRVSDRGK
PPRHATALVH IYVNETISNV SLVEALVGHS LYTPLDRDIA GDPESSFAAQ RSNILFGSLA
GVAGVVILIL AVVFIRHRIQ RETKSGYQAG KKETKDLYAP KQAPKNAKGK RGKKGKLHKS
PKPLGEEEEV SLQKSLKFNL DGVSDSPRIH LPLTYSPGSP DIGRHYRSNS PLPSIQLQAQ
SPSGSQKHQA VQDLPATNTF VGTGGDDNST GSDQYSDYSY KTSQSKYNNK QHPHRRVTFS
TTNPVQDMQD ASQQSYYDSG LEESETPSSK SSSGPRIGPL TLPEDHYERT TPDGSIGENE
HPENDIRSLP DVAMTGNCTT ECSELGHSDA CWMPGHPSPV RKTRNPPKLS TFVPYQERGS
LGRLANGSAR LGGEDPRSRL PPSRSAYSSS GHDANQDCPL EEMPLSVASE FPPTSPPNHT
PKREIYL
//
