ID H2M2S6_ORYLA Unreviewed; 740 AA.
AC H2M2S6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Exostosin-1c {ECO:0008006|Google:ProtNLM};
GN Name=ext1c {ECO:0000313|Ensembl:ENSORLP00000012723.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012723.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012723.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012723.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012723.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012723.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR RefSeq; XP_004074204.1; XM_004074156.2.
DR RefSeq; XP_011479447.1; XM_011481145.1.
DR AlphaFoldDB; H2M2S6; -.
DR STRING; 8090.ENSORLP00000012723; -.
DR Ensembl; ENSORLT00000012724.2; ENSORLP00000012723.1; ENSORLG00000010146.2.
DR GeneID; 101169374; -.
DR KEGG; ola:101169374; -.
DR CTD; 497281; -.
DR eggNOG; KOG1021; Eukaryota.
DR GeneTree; ENSGT00940000163960; -.
DR HOGENOM; CLU_013906_4_0_1; -.
DR InParanoid; H2M2S6; -.
DR OMA; RNRYMWN; -.
DR OrthoDB; 1220028at2759; -.
DR TreeFam; TF314231; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000010146; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0008375; F:acetylglucosaminyltransferase activity; IBA:GO_Central.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..390
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 475..723
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 740 AA; 86152 MW; 294FEB3FCB07ADA7 CRC64;
MQARKKYVLL GLCACCWVLL FYWGGGVQLR LLRLLVRQRG DLVRPWPNWT DRAFFPRYAH
LDELQTETGM AESPRQRRQA WSAIYKDSRC RMETCFDFSR CRRRGREGFR VYIYPSEKND
RVSESYRKIL ASIAESRYYT SDPREACLFV LGIDTLDRDQ LSGQFVSNVD DRIRGYPLWN
EGRNHLIFNL YSGTWPNYTE DLGFNIGQAI LAKASLNTEH FRPGFDVSIP LFSKDHPQKG
GERGWLVRNS TPPRRKYLLM FKGKRYLTGI GSDTRNALHH IHNGKDIVSL TTCRHGKDWE
KHKDARCDHD NLEYERFDYQ ELLHNSTFCL VPRGRRLGSF RFLESLQAAC IPVLLSNGWE
LPFSDVIQWN QAVIEGDERL LLQVPSTVRA VGNERVLALR QRTQMLWDAY FSSVDKIVLT
TLEIIKDRVF SHTSRNKYMW NSLPGGLFAL PEYSSHLEHF PFYYLGLGLS ASQEFTAVIH
AVSPLVSQSQ PIMKLLQVVS KSKYCSQIII VWNSEKPQPS RSKWPPMPVP LTVTDGRRKT
TSRFLPHVAI ETEAVLSLDE DTVLLTSEVN FAFLVWRSFP DRIVGYPSRS HFWDPLRHAW
GYTSKWTNEY SIVLTGAAFY HRYYHHLFSH YLPQSLRILV DRTSNCEDIL MNFLVSSVTH
LPPIKVAQRK QYKELPGPQG TKSAPWASSE HFNQRQECVN TFASWFGYMP LVHSQLRLDP
VLFKDQVSVF RKKYKDLERI
//
