ID H2M485_ORYLA Unreviewed; 975 AA.
AC H2M485;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor {ECO:0000313|Ensembl:ENSORLP00000013246.2};
GN Name=lrp8 {ECO:0000313|Ensembl:ENSORLP00000013246.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013246.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013246.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013246.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013246.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013246.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; H2M485; -.
DR STRING; 8090.ENSORLP00000013246; -.
DR Ensembl; ENSORLT00000013247.2; ENSORLP00000013246.2; ENSORLG00000010561.2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000154819; -.
DR InParanoid; H2M485; -.
DR TreeFam; TF351700; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000010561; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005901; C:caveola; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0021517; P:ventral spinal cord development; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..975
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017334672"
FT TRANSMEM 894..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 393..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 432..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 494..539
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 540..582
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 583..626
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 627..671
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 778..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 50..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 62..77
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 82..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 89..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 144..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 166..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 173..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 205..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 212..230
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 252..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 259..277
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 271..286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 291..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 298..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 310..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 339..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 975 AA; 107607 MW; 9717449DED546906 CRC64;
MTDTAEPSRR ILAMWTDIGK LVLLHLLLLE LRVAKGTLTE SECETGQFQC SNGRCIPSLW
RCDDDDDCSD NSDEENCPKK TCATTDFTCK NGQCLPSKWR CDGEPECADG SDEADAICSR
QTCPPEKFDC GGAASKCVSL SWRCDGERDC ENGADEEQCA ADAKACASKD FQCRNGKCIG
PTFVCDGDND CGDSSDEEKC SSPTCGQHEF RCNNSECIPA LWSCDGDPDC KDKSDESAER
CSRGKEPQKP RCPVGEFQCG SGECVHMNWK CDGDADCKDK SDEANCPLLT CRPDEFQCGD
GTCIHGTKQC NKVHDCPDYS DEAGCVNITK CDGPRKFRCK NGECIDSSKV CDNVKDCKDW
SDEPPKECGL NECADNNGGC SHICRDRRIG HECDCPSGYK LLDKKTCGDI DECENPDACS
QICINYKGDY KCECYEGYEM DPASKTCKAV GNSPYLMFTN RHEIRRIDLL RSEYTQVVPT
LKNAVALDVD VSTNKMFWCD LYHRKIYSAY INKASDSSQQ VTLIDSLHSP EGLAVDWVHK
NIYWTDSGNK SISVATGDGR KRKVLIATEL SEPRAIAVDP HQGFMYWSDW GEHAKIEKAG
MNGVDRQVLV SDHIEWPNGI TLDLSNRRLY WVDSKLHLLS SVDLSGGNRK VLLSSHHHLG
HPFALTVFED RVFWTDLEEE AIYSVNRLTG HDVAKVAEDL NNPLDLVVFH EQRQPKAPDT
CNMGSLPNGG CEYLCLKAPQ ITDHSPKYTC ACPDGMELGP DMRRCAVVRL RTTTTAAPTT
TTTTPITTTT TSTTTTSTTV RTTTPSTTST TTTPVITTQS STTRQALPQT TRRFTTTVHP
WSPTATSTEM AAAVSPTSTQ TPPLAPAAPD SSQREANANL SHRASDHYLI GNNITVAVLG
IVIPIVVIGL LCTGGYLVWR NWRRKNTKSM NFDNPVYRKT TEDDDDEIHI GRHSESIGHV
YPPRVALSLE DDGYP
//
