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Database: UniProt
Entry: H2M4Q3_ORYLA
LinkDB: H2M4Q3_ORYLA
Original site: H2M4Q3_ORYLA 
ID   H2M4Q3_ORYLA            Unreviewed;       528 AA.
AC   H2M4Q3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-OCT-2019, entry version 46.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000013422};
GN   Name=LOC101159772 {ECO:0000313|Ensembl:ENSORLP00000013422};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013422, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000013422, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013422,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000013422}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013422};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_011483650.1; XM_011485348.1.
DR   RefSeq; XP_011483651.1; XM_011485349.1.
DR   RefSeq; XP_011483652.1; XM_011485350.1.
DR   RefSeq; XP_011483653.1; XM_011485351.1.
DR   RefSeq; XP_011483654.1; XM_011485352.1.
DR   Ensembl; ENSORLT00000013423; ENSORLP00000013422; ENSORLG00000010708.
DR   GeneID; 101159772; -.
DR   KEGG; ola:101159772; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186595; -.
DR   KO; K05007; -.
DR   Proteomes; UP000001038; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    180    204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    277    302       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      145    307       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      314    486       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       15     53       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       91    141       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     35     53       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    114    130       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE        293    293       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   528 AA;  57796 MW;  78CD3F3C62654E6A CRC64;
     MMGAARVKRR FSAVVDGPVE EEEVMRLATS AADSPRAGGS PTGSGTPTSS SPTLALNGIV
     LSLQSNTNNA RKQSTIEESA EEIAGGEGGV RAGRVRLGKT SAKGRGAGGR GEGCSSSEQD
     SLSSPSTTSR RRCKRSSRRP QKRFVGKDGR CNVTFVNMSE RGQRYLSDLF TTCVDIRWRW
     MLVIFTLSFI LSWLLFGFAF WLIASAHGDL SIRLNPNPGS PVGSGEAGSG GGSGGEAVVE
     EPCFLQVNSF LAAFLFSLET QTSIGYGFRS VTEECPLAVL AVVLQCIVGC IIDAFIIGAV
     MAKIAKPKKR NETLVFSETA VVAQRDGKLC MMWRVGNLRK SHLVEAHVRA QLLKPRVTPE
     GEFLPLDNAD INIGFDTGTD RIFLVSPVTI VHEINEESPF FEMDKNTLEK DSELEVVVIL
     EGMVEATAMT TQCRSSYLAS EILWGHRFEP VLFEKKDCYQ VDYSFFHRTY EVPNTPSCSA
     KELEEQTYIE GSGSSFCYEN EVALQRISND ELDQNPERPS LAEHLHHN
//
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