ID H2M5E6_ORYLA Unreviewed; 618 AA.
AC H2M5E6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0000313|Ensembl:ENSORLP00000013671.2};
GN Name=entpd4 {ECO:0000313|Ensembl:ENSORLP00000013671.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013671.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013671.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013671.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013671.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013671.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR RefSeq; XP_011477612.1; XM_011479310.1.
DR RefSeq; XP_011477613.1; XM_011479311.1.
DR AlphaFoldDB; H2M5E6; -.
DR STRING; 8090.ENSORLP00000013671; -.
DR Ensembl; ENSORLT00000013672.2; ENSORLP00000013671.2; ENSORLG00000010898.2.
DR GeneID; 101172088; -.
DR KEGG; ola:101172088; -.
DR CTD; 9583; -.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263540; -.
DR HOGENOM; CLU_010246_6_0_1; -.
DR InParanoid; H2M5E6; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF354343; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000010898; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0006256; P:UDP catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 222
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 274..278
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 618 AA; 70861 MW; 4ACE2EBFB7E35895 CRC64;
MGRISFSCLF PASWHFSVSP QLLPRILIPS LRQLLFFSLL ICLIGLLYLL LVVGKGHVSW
ITRENNFHRH LARVTDVDAT DTSNPNLNYG LVVDCGSSGS RIFVYCWPRH NGNPHELLDI
RQMRDQHRKP VVMKIKPGIS ELAKTPEKAS DYMYPLLSFA AQHIPKNKHQ ETPLYILCTA
GMRVLPESQQ EAILEDLRTD IPVHFNFLFS DSHVEVISGK QEGVYAWIGI NFVLGRFNHG
DSDGEAEVEV HVPSIDQQDT LRRQRTAGVL DMGGVSTQIA YEVPKTVRFV SPQQEEVAKN
LLAEFNLGCD AHRTEHVYRV YVSTFLGFGG NAARQRYEEN LMRKTITRNK LLGEHFGETA
ESPLPDPCLP TDLEDQIGTS TEKLYLRGTG DFDQCRQILQ PFLNRTNDTH SSLNGVYQPA
IDYSNSQFYG FSEFYYCTED VLRMGGDYNA SKYAAAAKGY CATKWKTLQE RFDSGLYASH
ADYHRLKYQC FKSAWMYEVF HSGFSFPTNY KNLKTALLVY EKEVQWTLGA ILYRTRFLPL
RDIQQESLKG THSHWRHSFS FVNNHYLFLA CFFIVLLSII LYLMRLRRIH RLAVKHYTPS
SVPWLEEGLG PPMLPIIL
//