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Database: UniProt
Entry: H2M5E6_ORYLA
LinkDB: H2M5E6_ORYLA
Original site: H2M5E6_ORYLA 
ID   H2M5E6_ORYLA            Unreviewed;       618 AA.
AC   H2M5E6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0000313|Ensembl:ENSORLP00000013671.2};
GN   Name=entpd4 {ECO:0000313|Ensembl:ENSORLP00000013671.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013671.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000013671.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013671.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000013671.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013671.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_011477612.1; XM_011479310.1.
DR   RefSeq; XP_011477613.1; XM_011479311.1.
DR   AlphaFoldDB; H2M5E6; -.
DR   STRING; 8090.ENSORLP00000013671; -.
DR   Ensembl; ENSORLT00000013672.2; ENSORLP00000013671.2; ENSORLG00000010898.2.
DR   GeneID; 101172088; -.
DR   KEGG; ola:101172088; -.
DR   CTD; 9583; -.
DR   eggNOG; KOG1386; Eukaryota.
DR   GeneTree; ENSGT01100000263540; -.
DR   HOGENOM; CLU_010246_6_0_1; -.
DR   InParanoid; H2M5E6; -.
DR   OrthoDB; 180318at2759; -.
DR   TreeFam; TF354343; -.
DR   Proteomes; UP000001038; Chromosome 9.
DR   Bgee; ENSORLG00000010898; Expressed in animal zygote and 14 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006256; P:UDP catabolic process; IBA:GO_Central.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        222
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         274..278
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   618 AA;  70861 MW;  4ACE2EBFB7E35895 CRC64;
     MGRISFSCLF PASWHFSVSP QLLPRILIPS LRQLLFFSLL ICLIGLLYLL LVVGKGHVSW
     ITRENNFHRH LARVTDVDAT DTSNPNLNYG LVVDCGSSGS RIFVYCWPRH NGNPHELLDI
     RQMRDQHRKP VVMKIKPGIS ELAKTPEKAS DYMYPLLSFA AQHIPKNKHQ ETPLYILCTA
     GMRVLPESQQ EAILEDLRTD IPVHFNFLFS DSHVEVISGK QEGVYAWIGI NFVLGRFNHG
     DSDGEAEVEV HVPSIDQQDT LRRQRTAGVL DMGGVSTQIA YEVPKTVRFV SPQQEEVAKN
     LLAEFNLGCD AHRTEHVYRV YVSTFLGFGG NAARQRYEEN LMRKTITRNK LLGEHFGETA
     ESPLPDPCLP TDLEDQIGTS TEKLYLRGTG DFDQCRQILQ PFLNRTNDTH SSLNGVYQPA
     IDYSNSQFYG FSEFYYCTED VLRMGGDYNA SKYAAAAKGY CATKWKTLQE RFDSGLYASH
     ADYHRLKYQC FKSAWMYEVF HSGFSFPTNY KNLKTALLVY EKEVQWTLGA ILYRTRFLPL
     RDIQQESLKG THSHWRHSFS FVNNHYLFLA CFFIVLLSII LYLMRLRRIH RLAVKHYTPS
     SVPWLEEGLG PPMLPIIL
//
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