ID H2M5M0_ORYLA Unreviewed; 594 AA.
AC H2M5M0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Tripartite motif containing 8b {ECO:0000313|Ensembl:ENSORLP00000013752.2};
GN Name=trim8b {ECO:0000313|Ensembl:ENSORLP00000013752.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013752.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013752.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013752.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013752.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013752.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004080523.2; XM_004080475.2.
DR AlphaFoldDB; H2M5M0; -.
DR STRING; 8090.ENSORLP00000013752; -.
DR Ensembl; ENSORLT00000013753.2; ENSORLP00000013752.2; ENSORLG00000010965.2.
DR GeneID; 101172537; -.
DR KEGG; ola:101172537; -.
DR CTD; 559967; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000157919; -.
DR HOGENOM; CLU_036491_0_0_1; -.
DR InParanoid; H2M5M0; -.
DR OrthoDB; 4621775at2759; -.
DR TreeFam; TF333491; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000010965; Expressed in intestine and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd19838; Bbox1_TRIM8_C-V; 1.
DR CDD; cd19763; Bbox2_TRIM8_C-V; 1.
DR CDD; cd16580; RING-HC_TRIM8_C-V; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF19; E3 UBIQUITIN-PROTEIN LIGASE TRIM8; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 25..66
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 363..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 64967 MW; F3FA8E5B7DD99CEB CRC64;
MPASTMMASD MAETWRNCFE EELICPICLH VFSDPIQLPC KHNFCRGCIS EAWAKDSTLA
RCPECNHAYT QKPSLEKNHK LSNIVEKYNA LSVEKATTPA LQCILCRRGP PLPAVKVCLR
CNAPCCQSHV QTHLQQPCSA LGHLLVEAEA VKAWTCPQHD EYRLYHCEAE QTAVCQYCCF
ARCHPSHGHA VSDVELRRND IRQNLLRQQE RVEERVQEME EQLCKLDSDK CVVEDRVCEL
KEEVRMQYQR MNQLLEEDLG RTLEALDRAR ARFCQENAAQ VLALGEQRHE AQKLLSSIHT
AFSKAEELSF MKNTKPVKIL TDRCQACVGS ALPPYKVGNL NSKLFLSEIS KREKSLKRTL
EAPLTPPSSF LQSVPAFPSG QSSSSGAEKR KHSTAFPEGT GTAGKTVASG FKDLSSSSSS
SSSSLAKQPY LGSGSSSGEG QSSNPQPLAP CAPPHISESS GTGSGSGSLT NHHSGSVFSS
SHFPPGGSSS SHSSQQAVLP QYGGRKILVC TMDNCFCSGV PSVSGHRSHP PYPRSGSFAW
VNPQDYPPPP GLASGGPSMQ GLAVRDWIDA SQTHRHADFY GLYGQPSTKH YVTS
//
