ID H2M6G2_ORYLA Unreviewed; 642 AA.
AC H2M6G2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Transmembrane protein 62 {ECO:0000313|Ensembl:ENSORLP00000014056.2};
GN Name=TMEM62 {ECO:0000313|Ensembl:ENSORLP00000014056.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014056.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014056.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014056.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014056.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014056.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2M6G2; -.
DR STRING; 8090.ENSORLP00000014056; -.
DR Ensembl; ENSORLT00000014057.2; ENSORLP00000014056.2; ENSORLG00000011208.2.
DR eggNOG; ENOG502QTBN; Eukaryota.
DR GeneTree; ENSGT00390000016216; -.
DR HOGENOM; CLU_021197_1_0_1; -.
DR InParanoid; H2M6G2; -.
DR TreeFam; TF323442; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000011208; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd07401; MPP_TMEM62_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041871; MPP_TMEM62.
DR PANTHER; PTHR14795; HELICASE RELATED; 1.
DR PANTHER; PTHR14795:SF0; TRANSMEMBRANE PROTEIN 62; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..642
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017326648"
FT TRANSMEM 435..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..263
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 642 AA; 72591 MW; 1CFAEB4094B65072 CRC64;
MLRLFGALVL LGLALACITS WVLDSYDTAW HPKRSVRPPA VSGSEASTPP YPNGELSNIF
WFIQVSDIHI SRFLDPRRTP EFEKFCTDTV NAIKPALVLA TGDLTDAKTE NNVGSDQHEV
EWQAYHGVLK RSRVMERTKW IDIRGNHDAF NIFSLDSINN YYRKYSANQK MGSFHYIHQT
PFGNYSFVCV DATLTPGPKR PFNFFGILNQ TQMNLLDTFR AESQRSNQSI WFGHYTTSTI
VSPSPGVRHL MSSAVAYLCG HLHTLGGMMP VLHSRHPHGT LELELGDWMD NRRYRVLAFD
HDLLSFSDLR FERWPAVLIT NPKDAQYLHP GLEPLGRMRK STHIRILAFS EASITAVHVS
IDGEPVGRAN SAGGPLYVLP WDPSLYLAGL HTIRVTVEDS AGRSSELEQL FTLEDGLTVS
FSFPQSFILL TDHYIVGRFA FVFTVLLNVC VLLAFRFLRF PAGRGLPSQI CLSLHLVSKI
NTFFYSLLLF NLCTALGPWF FGELVDGHSG ACFAFGVFID GHFLEGSRTY IVGVIQVLSF
NMPLTSYLCW CLHHRYRGNT FRSHFQRSGL RCWTLVLHLF VLLLLTWQAH SCYFLLETYG
LLAFLMSPIH TWALLLSLLL VYRAWTGPAP LICGNSRSAS RS
//
