ID H2M879_ORYLA Unreviewed; 1277 AA.
AC H2M879;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 3 {ECO:0000313|Ensembl:ENSORLP00000014691.2};
GN Name=mapk8ip3 {ECO:0000313|Ensembl:ENSORLP00000014691.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014691.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014691.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014691.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014691.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014691.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR AlphaFoldDB; H2M879; -.
DR Ensembl; ENSORLT00000014692.2; ENSORLP00000014691.2; ENSORLG00000011718.2.
DR eggNOG; KOG2077; Eukaryota.
DR GeneTree; ENSGT00940000153496; -.
DR HOGENOM; CLU_003841_0_0_1; -.
DR TreeFam; TF313096; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000011718; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 6..94
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 487..555
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 178..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..161
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 403..515
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 178..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1277 AA; 141312 MW; 5BF7796A01349D38 CRC64;
MMEIDEVVYQ DDYGSGTVMS ERVSGMANSI YREFERLIRS YDEEVVKELM PLVVNVLENL
DAVLIENQEH EVELELLKED NEQLITQYER EKALRKQAEE KFIEFEDALE AEKKDLQMQV
EFLELQGKQL ELKTKNYSDQ ITRLEERESD LKKEYNALHQ RHTEMIQTYV EHIERSKLQQ
AGSNSQSEGT GCGRTSKAER PPSLSLYPSG EGMVRGGLGG ARMVPGKDIW QVSELGCSTF
SSAYQEDGSE SDSVAATPSS TGSKSNTPTS SVPSATVTPI NEGFLLQSDF DMVPAGNRRK
SGKRLSRNME VQVSQETRNV SIGMGSSDEW SEFQEIIDST PELEHSVYGG GNSPCQGIVN
EAFGINTDSL YHEIKDAKSD IIGDVDAGLQ LLGCNVSGMG KEVENLLTEN KQLLETKNAL
NIVKNDLIAK VDELSGEQEV LREELEAVRQ SKNKVDARIK ELEEEIKRLK AEALGASRDS
KDEGDDRRRF TRVEMARVLM ERNQYKERLM ELQEAVRWTE MIRRKRSPPS AVSYSFLSQS
FARLFSTSSS PPPVKRPYYS VNIHYKSPSP AGFTQRRSHT MCQISTSNRT LEFFPEDDSA
LLARREQRRE QYRQVREHMR RDDGIMQACG WSVPSRLKQT TNDKEDNRMK NVPVPVYCRP
LVEKDPNRKL WCAAGVDLTG WRASTPGMGS AKSLSGSGDP LQAEEEGSDK KNNHTSPEKK
KTKELQETDS MNSRVWILTS THSASKVVII DANQPGSLVD QFNVCNAHVL CISSVPAASE
SDYPAGEIVL DPGDGGAGSG DDASGVEGML AGITLVGCAT NCSVARSNCS SRTDTPIMDK
GQGESPTAPP MNGKIHPTQS AEEATEATEV PESTANQAEM RSGPPGPFME HVFTDPQPRH
ADDGSQEAKN YTSVAPTMWL GAQNGWLYVH SAVGNWKKCL HSIKLKDSVL SLVHVKGRVL
VALADGTLAI FHRSEDGQWD LSNYHLMDLG RPHHSIRCMA VVHDKVWCGY KNKIHVIQPK
SMQIEKSFDA HPRRESQVRQ LAWIGDGVWV SIRLDSTLRL YHAHTHQHLQ DVDIEPYVSK
MLGTGKLGFS FVRITALLIG GNRLWVGTGN GVIISIPLTE TVVLHRGQLL GLRANKVSPT
SGGVIHVYGD DGSEKSSGSF IPYCSMAQAQ LCFHGHRDAV KFFVSVPGNV LATLNGSVLD
SPSEGQSSTA PTENEAQSVQ NVLVLSGGEG YIDFRIGDGE DDETEEGESG SASQMKPALS
KAERSHIIVW QVSYIPE
//
