ID H2M8A1_ORYLA Unreviewed; 627 AA.
AC H2M8A1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000014714.2};
GN Name=terfa {ECO:0000313|Ensembl:ENSORLP00000014714.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014714.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014714.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014714.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014714.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014714.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004067316.1; XM_004067268.2.
DR AlphaFoldDB; H2M8A1; -.
DR STRING; 8090.ENSORLP00000014714; -.
DR Ensembl; ENSORLT00000014715.2; ENSORLP00000014714.2; ENSORLG00000011741.2.
DR GeneID; 101162825; -.
DR KEGG; ola:101162825; -.
DR CTD; 192316; -.
DR GeneTree; ENSGT00940000158316; -.
DR HOGENOM; CLU_879867_0_0_1; -.
DR InParanoid; H2M8A1; -.
DR OrthoDB; 207546at2759; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000011741; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0070187; C:shelterin complex; IBA:GO_Central.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0098505; F:G-rich strand telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0032208; P:negative regulation of telomere maintenance via recombination; IBA:GO_Central.
DR GO; GO:1905839; P:negative regulation of telomeric D-loop disassembly; IBA:GO_Central.
DR GO; GO:0031848; P:protection from non-homologous end joining at telomere; IBA:GO_Central.
DR GO; GO:0070198; P:protein localization to chromosome, telomeric region; IBA:GO_Central.
DR GO; GO:0032210; P:regulation of telomere maintenance via telomerase; IBA:GO_Central.
DR GO; GO:0006278; P:RNA-templated DNA biosynthetic process; IEA:GOC.
DR GO; GO:0061820; P:telomeric D-loop disassembly; IBA:GO_Central.
DR GO; GO:0031627; P:telomeric loop formation; IBA:GO_Central.
DR CDD; cd11660; SANT_TRF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.25.40.210; Telomere repeat-binding factor, dimerisation domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR013867; Telomere_rpt-bd_fac_dimer_dom.
DR InterPro; IPR036507; Telomere_rpt-bd_fac_dimer_sf.
DR InterPro; IPR030657; TERF2.
DR PANTHER; PTHR46833:SF1; TELOMERIC REPEAT-BINDING FACTOR 2; 1.
DR PANTHER; PTHR46833; TELOMERIC REPEAT-BINDING FACTOR 2 TERF2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF08558; TRF; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF63600; Telomeric repeat binding factor (TRF) dimerisation domain; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 569..622
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 574..626
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 310..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 251..278
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 321..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 70801 MW; EC66574B7D76F7F3 CRC64;
MAAKKCVNSD LVSVERVVNR WIVDYNLSLA LELFKKQQFE DFNEVRNVLS VVMKRPVEAT
SDMPLKIRML QFLGRINEGE NLELIYDPGT PVTPLESALL LLENIMEAFG IPQQDWEDAS
NSLKVMIVAT FIKNGNFDKA AQMLNKYFPK PVGRVRNILE GLIRQKNKTS NSFSFQLFKQ
EMLAFVQRLC YFDVPFSYRA AQELLTMRLE VDGDDDAEEI EQEVTNATPS PQKNPVPFQP
CKHLIILRSR LESVYNALSE DEKTFAQLEQ EVETEIQDRD GLHLEHSSDS ETLDDLNAER
ADLPQRNVCS PMEASPAEQP PQTDDGPQIQ ARSLSKEHYT VARLVTEPDS QSSSQYTTGL
EELETEAGTE KPPQVPDGSS EKELQCPVSD GETAIPTPKR PRRSKKTAAR AAASVLETSS
DSEDNSVEKR KEMQEETPPC QSNKSKSRNS GTSKRHSSGL QDDYITPVKR PVRQPSTGSS
KKKSSSTGRS ISPESVGESP ITESCLDSPS GPCHQHPVPQ KSSTPEQAFP NTKWKSLFRT
AKESKVTWNN EEMEFLLKDT KGSNESIKSN SGHKRKWTDQ ETEMLKEGVK TFGEGNWSKI
KSYYDFKDRT NVNLKDRWRT MKNLKMV
//
