ID H2M8R5_ORYLA Unreviewed; 259 AA.
AC H2M8R5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039666};
GN Name=hdhd2 {ECO:0000313|Ensembl:ENSORLP00000014886.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014886.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014886.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014886.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014886.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014886.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00007958}.
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DR AlphaFoldDB; H2M8R5; -.
DR Ensembl; ENSORLT00000014887.2; ENSORLP00000014886.2; ENSORLG00000011885.2.
DR eggNOG; KOG3040; Eukaryota.
DR eggNOG; KOG4779; Eukaryota.
DR GeneTree; ENSGT00940000155805; -.
DR HOGENOM; CLU_718736_0_0_1; -.
DR TreeFam; TF314344; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000011885; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd07509; HAD_PPase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006357; HAD-SF_hydro_IIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006355; LHPP/HDHD2.
DR InterPro; IPR002645; STAS_dom.
DR NCBIfam; TIGR01460; HAD-SF-IIA; 1.
DR NCBIfam; TIGR01458; HAD-SF-IIA-hyp3; 1.
DR PANTHER; PTHR19288; 4-NITROPHENYLPHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR19288:SF46; HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13344; Hydrolase_6; 1.
DR Pfam; PF13242; Hydrolase_like; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1..94
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 259 AA; 28435 MW; D77818A5FA1F0EBC CRC64;
MKASWASNMV ARPDKRALKA VLIDLSGTLH IDDTAVPGAQ EALKKLRNAS VTVKFVTNTT
KESKRNLLER LHRLNFDVQE NEIFTSLSAA RSLIEQKNHR PLLLVEDSAL EDFNGIDTSE
PNAVVIGLAP EHFNYQTLNK AFRMILDGAP LIAIHKARYY KRKDGLALGP GPFVTGLEYA
TDRKASVVGK PEKTFFMQAL SDLGCSPSEA VMIGDDARDD IGGAQNAGML GILVRSGELT
FLPSRLNSRH ACRCFVCTH
//
