ID H2MB77_ORYLA Unreviewed; 792 AA.
AC H2MB77;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=cdh19 {ECO:0000313|Ensembl:ENSORLP00000015798.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015798.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015798.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015798.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015798.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015798.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR RefSeq; XP_011487369.1; XM_011489067.1.
DR AlphaFoldDB; H2MB77; -.
DR STRING; 8090.ENSORLP00000015798; -.
DR Ensembl; ENSORLT00000015799.2; ENSORLP00000015798.1; ENSORLG00000012613.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000166818; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR InParanoid; H2MB77; -.
DR OMA; YVCEGTQ; -.
DR OrthoDB; 3667774at2759; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000012613; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF421; CADHERIN-7-LIKE; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..792
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003565229"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 153..261
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 262..377
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 378..482
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 482..594
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 792 AA; 88179 MW; 66A62AC005B4BBB9 CRC64;
MPTSRVLAIV TVFSMIPGGI LSDIKGSRGL ETQHLAQKST YPQRRLKRSW IWTQPFVPEE
DPSLGVIGQI KSDSDRGDLS IKYILTGEGA GNIFEIDEYS GEIRKLKKLD REEKAFYVLQ
AQAINRNTNE PEEPQSEFIV KVQDINDNVP QFQNEPYVSS IPEMSPAGTT VAQVTATDAD
DPMFGNNAKL IYSILQGEPY FSVEPKTGIV VTSWPDLDRE TRDEYLVVIQ VQDMLGLSGG
YSSSTTLTVI LTDVNDNGPT FQRQLYTFNV PENAAIGSTV GRIIADDGDI GINARMTYSL
EDDLEESSTF IIKTDPVTQE GQLLLAKPLD YESKRRYKMA VEAINDHVDT RFLPLEEFKD
STAIKIVVRD VDEPPAFVSP VYEWKVPENA AVGTVVGSIS ARDTDTHNSP IRYSIDKRSD
ATKSFRIDAN NGTIAIVKAL DRETSSWHNF TIEAKEETQN HLSSSVAVFI KVLDINDNVP
RLARDYQPYI CEGTQAGELI QLLSAVDVDN PEEGHHFYFS MVPEKHINPN FTIRDNQDNT
AGIVTRRSTF TLKDRALYFL PVVVADSGTP TLSSTSTLTI SVCRCQPAGH CPTAGVERLL
LSLDPGLQTV LGILVCLVTI SVLSVLMLLL RRHKRKQQEG LDVGLKELEL PDTVSQKVLH
YGETGGRRVN FCQPAIPLHP QPRRRERRLR KEEVRASIRM SLGESHFIGP EDEVFRQFIL
DRLAEADQDP YVPPFDCLQT YAYEGSGSPT GSLSSLDSLT GETELVQPLY NPRAHVVKLS
PWCGSGEEDT TF
//
