ID H2MBL0_ORYLA Unreviewed; 492 AA.
AC H2MBL0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=IRF tryptophan pentad repeat domain-containing protein {ECO:0000259|PROSITE:PS51507};
GN Name=LOC101161045 {ECO:0000313|Ensembl:ENSORLP00000015933.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015933.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015933.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015933.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015933.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015933.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011472561.1; XM_011474259.1.
DR AlphaFoldDB; H2MBL0; -.
DR STRING; 8090.ENSORLP00000015933; -.
DR Ensembl; ENSORLT00000015934.2; ENSORLP00000015933.2; ENSORLG00000012712.2.
DR GeneTree; ENSGT00940000166222; -.
DR HOGENOM; CLU_031544_1_1_1; -.
DR InParanoid; H2MBL0; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000012712; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF20; LOW QUALITY PROTEIN: INTERFERON REGULATORY FACTOR 4-RELATED; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 15..123
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
SQ SEQUENCE 492 AA; 55820 MW; 60424FA703A477CE CRC64;
MNLDVDYGGS GSSGNGKLRQ WLIEQVDCGK YPGLVWENDE KSIFRIPWKH AGKQDYNRDE
DAALFKAWAL FKGKFREGID KPDPPTWKTR LRCALNKSND FEELVERSQL DISDPYKVYR
IIPEGAKKSQ SSISNHKTLK LNINLSGSCG DCKFLRNEEH IFIYFAGFPV GPRQEDSPTS
PVGYQMHPSY PTMPTQMTPY ISSPECSWRD YCPEQTSLTE LSFAQCPCPP RSLPWQTPSI
ENGYQLRASI YSYGPDSQPS PFSLDASIRS AEALSDLRLH VSVYLRETLV REATVTSPEG
CHLTPCPPEK HYLTAGGPEV VPLPVDSLSA LRRTDECPPS PPSVLERGVL LWMSADGLYA
RRLCQSRVYW QGGLSPYGDK PNKLEREVTC KLLHTQDFIT EIQSFGFHGR PPSRFQVLLS
FGDECLDPQR QRRTLTVQVE PLFARQLLYY AQQTSSHYYR SYEHPGVTDH INASEDYQRA
ITHHHAAASL QE
//
