ID H2MC68_ORYLA Unreviewed; 1122 AA.
AC H2MC68;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSORLP00000016147.2};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSORLP00000016147.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016147.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016147.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016147.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016147.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016147.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR RefSeq; XP_004069108.1; XM_004069060.2.
DR AlphaFoldDB; H2MC68; -.
DR Ensembl; ENSORLT00000016148.2; ENSORLP00000016147.2; ENSORLG00000012890.2.
DR GeneTree; ENSGT00940000156915; -.
DR HOGENOM; CLU_031196_0_0_1; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000012890; Expressed in muscle tissue and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 510..703
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 205..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1055
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 126698 MW; 1A3BEE3100F065F1 CRC64;
MLKFKAFCLD YWQFLCLQPL HVFYKSVEGD GPGTEVGTSV DSSSCYSYVP VTHRGGLGPE
RLDSQLYGQI LLAGHPRTRR SKLQHSQSIL RKQAEEEAIK RSRSLSESYE LSSDLQDKQV
EMLERKYGGR FITRHAARTI QTAFRQYQMN KNFERLRSSM SENRMSRRIV LSNMRMQFSF
EGPEKFNSSY FEGKQVSLTD GGTKVGALVQ SDHDGERGQS KTSTPQSDFT DAITELEDAF
SRQVKSLAES IDDALNCRSL HGEDGQPEQR RRDKDMDKQV EPSQSSPDRC KLEEMTASYS
DVTLYIDEEE LSPPLPLSLS VDRPSSTESD LPQRSLNSSQ DYWSLVHKDD KGDTDTSCRS
TPSLECQEQR LRVEHLPLLT IEPPSDSSVE LSDRSDPSSL KRHNAYERSN QQSSPKHVSR
SLPPRGPSRE EGHRPRQLDP HVVVNGTPNR QSKSESDFSD GDNDSINSTS NSNDTINCSS
ESSSRDSLRE QTLSKQTYHK ETRNSWDSPA FSNDIIRKRH YRIGLNLFNK KPEKGTQYLI
DRNFVPDTPV GVAHFLLQRK GLSRQMIGEF LGNRQKQFNR DVLDCVVDEM DFSAMELDEA
LRKFQAHIKV QGEAQKVERL IEAFSQRYCI CNPGVVQQFR NPDTIFILAF AIILLNTDMY
SPNVKPERKM KLEDFVKNLR GVDDGEDIPR EILVGIYERI RKRELRTNED HVSQVQKVEK
LIVGKKPIGS LHQGIGCVLS LPHRRLVCYC RLFEVPDPNK PQKLGLHQRE IFLFNDLLVV
TKIFQKKKNS VTYSFRQSFS LYGMQVLLFE NQYYTNGVRL TSAIPGADIK VLINFNAPNP
QDRKRFTDDL RESIAEVQEM EKYRIESELE KQKGVVRPSM SQSAGLKKDT GNGTLSRASL
DDSYAIGEGL KRSALSSSLR DLSDAGKRGR RSSAGSLDSN LEGSIISSPH IRRRSPSSRD
CPSRHSGHSL PSSSSLLGSL FGTRRVKSPS PTPQLSHPTL MAHSPHPLNL HHTARVETDT
PAPMIPHNAP FCHMGQNPPP YHHHHHYHPP AHLKHPPHQY HPPPPHNQQL TYPHSQHGHG
GHSTHPPHPG HGPHLHGPSP PAAPPQGSSN SKSKHSGIST VV
//