ID H2MCB7_ORYLA Unreviewed; 1389 AA.
AC H2MCB7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=CASK interacting protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101167247 {ECO:0000313|Ensembl:ENSORLP00000016200.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016200.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016200.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016200.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016200.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016200.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSORLT00000016201.2; ENSORLP00000016200.2; ENSORLG00000012927.2.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00940000158256; -.
DR HOGENOM; CLU_003619_1_1_1; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000012927; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 106..138
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 139..164
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 182..214
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 214..246
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 275..341
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 464..527
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 533..597
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 343..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 148802 MW; BF208C53AA42C9D3 CRC64;
MGKEQDLLVA VKNGDLLLAH KLLSKVKCNK TNRKHTPLTK GRPKNLIENK FKETKSELLG
STKKLNVNYQ DSDGFSALHH AALTGPTELL SLLLEAQATV DIKDVNGMRP LHYAAWQGKS
DSVLLLLRAG ASVNSLSCDG QIPLHLSAQY GHYEVVAQLL LSSNMVTTLL EGDGGGDSSD
WPSTTPLHLA ARNGHKDIIK LLLKAGIDMN RATKAGTSLH EAALYGKTEV VRLLLDAGIN
VNVRNTYNQT ALDIVNQFTT STASREIKQL LREASSSLQV RAVKDYWNLH DPTALNLRAG
DLVMVLEQHP DGRWKGHVHD TQRGTDRVGF FPPSVVEVLS RRAGVPPGSQ LSAPTSPPQD
IWVLRSSPTG DRNSVGSTGS VGSSRSAGSG QSSESGHKQN GTHSRPNDDS GKLSPSAGEK
GERICITVAD QSKHADGSTG GSRRPVNSSA HKGFVRPEQL FEGKDSEAIY QWLSEFQLEQ
YTSNFIKAGY DVPTISRMTP EDLTAIGVTK PGHRKKISME ISKLSIPEWL PDYIPSDLGE
WLNVIGLPQY QKRLCENGYD AIAIVKDITW EDLQEIGITK LGHQKKLMVA VKRLSDLQRS
RNISDIAAGR GGRRKPSAPL ELVAIEHNVA NPHNPHMQTD GPANNCCSSP RTPRALLSFQ
DSELSTELQS AMMGRMGGVA SEAFGIRGVA SAAILAAMSV SQESISKRSR GSGNSGNSGH
CQDHSSGSSR RCEEGSGRCE GEEAGRIKKG SPGGGNRLMP TEMPEHQCWS AVSNKLPFST
ATPPLTPSKM PRFAYPAVPS KTNQLQSPNR LAPAPPSSPS PQRSPTKKAP AVQQVQTGLN
GSSQRALFMP LPGAGSAPPA QPPVELESQK KRTQSLTRYA LSDGEPDEDE DPALSRSSAS
PSAMPSYATL SRRTPRAPAT QRHINRSHSF AVRSRHKGPP PPPPKRMSSV CSSPSHQQRN
TSVGEVESTG SVRSIAAKLE GSSPSRRIDI PPPHMPGSPV FSPVSSGFSH GFPPNGVPHF
QPPPALSLRR NDGGADRQEV TSEEERVRKN QKESRTPSAS SAPQRQVSGE HLPFAEEGNL
TIKQRPRMAS TSQAPPDISS PSEGAAQTPN SLELPEFNLK ESDTVKRRHK PKDASTPPET
CTRDDIHPQN NCSYTHHGAR AANGEEDHRP EKVFLRFGSI GKGPKPPVSS KPSSPLRQSP
NTGPTSPQNA APSVRAGPQM TIPKLTSAQI HTVSSHHGGN IHLPSPKPVR HPPMVTPKPE
SPQTTSRLLQ PCTPPTPRRG PKLSTAHTLS LTAPPSPSLP PCSLPPAPSA QAGKAAAALD
GVAGLEVLAQ KRLEQTSTSL EAALKVVENK LAQGSCVDGP GSVKAAGNIL DDIGSMFDDL
ADQLDAMLE
//
