ID H2MCE6_ORYLA Unreviewed; 648 AA.
AC H2MCE6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=XK-related protein {ECO:0000256|RuleBase:RU910716};
GN Name=xkr5a {ECO:0000313|Ensembl:ENSORLP00000016231.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016231.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016231.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016231.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016231.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016231.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU910716}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU910716}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000256|ARBA:ARBA00008789,
CC ECO:0000256|RuleBase:RU910716}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004083629.1; XM_004083581.2.
DR AlphaFoldDB; H2MCE6; -.
DR Ensembl; ENSORLT00000016232.2; ENSORLP00000016231.2; ENSORLG00000012952.2.
DR GeneID; 101161208; -.
DR KEGG; ola:101161208; -.
DR CTD; 497102; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT01070000253766; -.
DR HOGENOM; CLU_025738_1_0_1; -.
DR InParanoid; H2MCE6; -.
DR OrthoDB; 3060440at2759; -.
DR TreeFam; TF316454; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000012952; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR PANTHER; PTHR16024; XK-RELATED PROTEIN; 1.
DR PANTHER; PTHR16024:SF15; XK-RELATED PROTEIN 5; 1.
DR Pfam; PF09815; XK-related; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910716};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|RuleBase:RU910716};
KW Transmembrane helix {ECO:0000256|RuleBase:RU910716}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 264..282
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT REGION 498..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 70858 MW; ED138C6FB82C59E0 CRC64;
MINAAAGAVA RRMPSATRRS GCWIAWCHAV LFGVSALVIV AERSALIYCI GFYLWNEETQ
WAGLTLGLFL PGTAVQLLSV KWYYDDGDDR RCYLSVIHIL HLGIFKRLWD CMKSVLRRQG
SVSELGVVVM QQADVAALWV LEALVLTLPQ SLLQAYVVVS TDVGITSPVA YCCGLCVLSV
SWALVLYSRA CCLIRPGHLA MPPAALLCQL VWRAGMLGAR VTCLMFFARV FHWWVCGVAG
FHWLTASFWL VSQQPDICTG PWCWRAFNGV LGLVHVFLFL NVKDGPSRYR MASFYAFMLV
ENATLLLTAS DFLSEASWDN MTLPTSVLCC FLLGATSLVL YYRFLHPKST EISQGTSRHH
MGSTCIEQGE SSFSLGDKSL PPPSSQTHGS FSLSGVAGSL LEHPGNCEGR SNSSCPCYHH
HWLLIRLALK TGDLGKINRA YGAGGAAAIL DMDDNNQEFK SNEGITITAG GSCEAVSTSE
SQGKGLAPLS DCKDEFQSIS EPTSTEHPDE EEDSLEMESP MESPVSDFKR SSPEGKSVFG
DSPEPYFCPT ESSSTLYFSA DPQSPSSASN PRLDRETGSL ELGGRLNSIP SDPALHRDVR
GLMGRVGQRC ISTPKLDLGV LDSASSIPHL TGPRRQLIMS RRDEDDHF
//
