ID H2MCT7_ORYLA Unreviewed; 1284 AA.
AC H2MCT7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Valine--tRNA ligase {ECO:0000256|ARBA:ARBA00024407};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN Name=vars1 {ECO:0000313|Ensembl:ENSORLP00000016375.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016375.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016375.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016375.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016375.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016375.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004078049.1; XM_004078001.1.
DR STRING; 8090.ENSORLP00000016375; -.
DR Ensembl; ENSORLT00000016376.2; ENSORLP00000016375.2; ENSORLG00000013063.2.
DR GeneID; 101158795; -.
DR KEGG; ola:101158795; -.
DR CTD; 7407; -.
DR eggNOG; KOG0432; Eukaryota.
DR eggNOG; KOG0867; Eukaryota.
DR GeneTree; ENSGT00940000157775; -.
DR HOGENOM; CLU_001493_0_1_1; -.
DR InParanoid; H2MCT7; -.
DR OrthoDB; 5473263at2759; -.
DR TreeFam; TF300648; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000013063; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IBA:GO_Central.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR CDD; cd10294; GST_C_ValRS_N; 1.
DR CDD; cd00817; ValRS_core; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.287.380; Valyl-tRNA synthetase, C-terminal domain; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR HAMAP; MF_02004; Val_tRNA_synth_type1; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR037118; Val-tRNA_synth_C_sf.
DR InterPro; IPR019499; Val-tRNA_synth_tRNA-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF118; VALINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR Pfam; PF10458; Val_tRNA-synt_C; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 80..208
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 264..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1214..1283
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1284 AA; 144457 MW; ACC3D44F48EE5588 CRC64;
MATLYVSPHP DHFRSLLALI AAEFSPSSRP QIITEDPPSS LNVHSRPALR LGTGVSDSVL
CGGSAVAWYL ASQGKRAGVD LKQQSQVWQW LSFAENELTP LSCAVAFPLM GVTGVDKKIQ
QNSRAELMGI LNVLDQALAP RTFLVGESIT LADMAVATAV LLPFKYALEP SDRKLIINVT
RWFTTCINQP QFLAVLGEIP LCERAVSVTP NTNAAAKAKN AQTTPGVDSA AAAAAVVAAA
TNGPPKTEAQ LKKEAKKREK LEKFQQKKEM EAKKKTQPAA EKKVKPEKKE LGVITYNIPT
PAGEKKDVVG SLPDSYSPQY VEAAWYTWWE KQGFFKPEYG RKSVGEKNPR GIFMMCIPPP
NVTGSLHLGH ALTNAIQDCL TRWHRMRGET TLWNPGCDHA GIATQVVVEK KLMRERGLSR
HDLGRENFIQ EVWKWKNEKG DRIYHQLKKL GSSLDWDRAC FTMDPKLSYA VQEAFIRMHE
DGVIYRSKRL VNWSCTLNSA ISDIEVDKKE LSGRTLLPVP GYKDKVEFGV LVSFAYKVEG
SDEEVIVATT RIETMLGDTA VAVHPADPRY QHLKGKMVLH PFCDRKMPIV LDDFVDMSFG
TGAVKITPAH DHNDYEVGER HSLAFINILD ENGLLINVPP PFLGMKRFEA RKAVLQALKD
RGHFKEIKDN PMVVPVCSRS KDIVEPLLKP QWYVSCRDMG REAADAVREG RLKIIPDHHL
KTWFNWMDNI RDWCISRQLW WGHRIPAYFV TVSDPSVKAG EDMDGHYWVS GRSEVEAREK
AAKRFNVSAD KITLRQDEDV LDTWFSSGIF PFSIFGWPNE TEDLNVFYPG TLLETGHDIL
FFWVARMVMM GLKLTGKLPF KEVYLHAVVR DAHGRKMSKS LGNVIDPLDV ITGISLEGLH
AQLTDSNLDP VEVEKAKQGQ KSDYPNGIPE CGTDALRFAL CAYTSQGRDI NLDVNRILGY
RHFCNKLWNA VKFAMKTLGD TFVPLEKAQL SGEESVSDRW ILSRLSAAVA LCDAGFKAYD
FPAITTAVYN FWLYELCDVY LESVKPVFSK AEEDGDRQRE AMVCRQTLYT CLEVGLRLLS
PLMPFVTEEL YQRLPRRQPQ TDPPSICVTA YPDSKEFCWN SEEVDLNMEF IMTVVRTIRS
LRADYNLTKT KADCYLQCID SATVSLVQKY SLQIQTLSYS QAVIPLTASE PVPQGCAVAI
ASDRCTVNLM LKGLIDVEKE VTKLLTKKGD LEKQLEKLQE KMAKSDYKEK VPVKVQEQDA
EKLRQSQAEL EKVKEAIDNF RKMM
//
