ID H2MCW9_ORYLA Unreviewed; 1015 AA.
AC H2MCW9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 3 {ECO:0000313|Ensembl:ENSORLP00000016408.2};
GN Name=scube3 {ECO:0000313|Ensembl:ENSORLP00000016408.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016408.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016408.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016408.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016408.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016408.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_011475713.1; XM_011477411.1.
DR AlphaFoldDB; H2MCW9; -.
DR STRING; 8090.ENSORLP00000016408; -.
DR Ensembl; ENSORLT00000016409.2; ENSORLP00000016408.2; ENSORLG00000013086.2.
DR GeneID; 101160318; -.
DR KEGG; ola:101160318; -.
DR CTD; 222663; -.
DR GeneTree; ENSGT00940000153185; -.
DR InParanoid; H2MCW9; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000013086; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR PRINTS; PR00907; THRMBOMODULN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1015
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017383311"
FT DOMAIN 34..74
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 305..345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 346..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 385..425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 825..937
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 350..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1015 AA; 111684 MW; B26D80C678DF9E0E CRC64;
MYLHALIRAS VGFVGFCLVA FVQQSASGSK TTQDVDECAE ALDNCSIDAI CQNTPKSYKC
ICKSGYKGDG KHCEDVDECA TEYNGGCVHE CINIPGNYRC TCYDGFRLAH DGHNCLDVDE
CSEGNGGCQQ ICVNMMGSYE CRCREGFLLS DNQHTCIQRP KVHLEGTKEG PTCMDKNHGC
AHICREAPKG GISCECRPGF QLTRNMKDCK LTCNYGNGGC QHICEETDNG PKCSCHMKFV
LHSDGKTCVG ERSVQSQAAP QLFPNETCAV NNGGCDSTCH DSVTGVRCSC PVGFTLQPDR
KTCKDIDECR LNNGGCDHVC RNTVGSFECS CKKGYKLLTN ERTCQDIDEC SFDRTCDHFC
VNSAGSFQCL CHKGYVLYGV AHCGDIDECS INRGGCKYGC INTLGSYECT CPPGHKLHWN
RKDCIELVKC PAGLVAPKAT LSCSKAGKKE SCSLTCASKA HYLSESDNSY SVSCGIPVLR
GKSSTRLNSS SSQSCIETLA PPVKEKASVK IKNAKCYLHP KLTGRTEDRG RMLGPGGGQP
CSNCLVTFVN LKCDSTKKAK GRRARNSSNK EVTRITLELE AEVKPGDTTG SCNLSCQRQR
MEKQMKTYIK ALKKSINQER FLIRVAGLEY EVAQKLPQGA PIQENCGPGS ERDSGRCVRC
LPGSYYHGEQ ERCVQCPPGT FQEKEGQLAC DLCPGSDGHG PVGARNISSC AGQCSTGSFS
SDGFQPCLPC PHGTYQPDLG RTLCFPCGGG LGTKKEGASS FHECEVKVQC SPGHFYNTTV
HRCIRCPVGT YQTEFRQNYC ISCPGNTTTD FDGATSVSQC KNRQCGGEMG EFMGYIESPN
YPGNYPANVE CIWNINPPSK RKILIVVPEI FLPSEDECGD VLVMRKNWSA TSITTYETCQ
TYERPIAFTA RSRRLWINFK SNEANSARGF QIPYVTYDED YEQLVEDIVR DGRLYASENH
QEILKDKKLI KTLFDVLAHP NNYFKYTTRE SNEMLPRSFI RLISSKVSAF LRPYK
//
