ID H2MEC2_ORYLA Unreviewed; 792 AA.
AC H2MEC2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Cadherin-20 {ECO:0000256|ARBA:ARBA00040456};
GN Name=CDH20 {ECO:0000313|Ensembl:ENSORLP00000016927.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016927.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016927.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016927.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016927.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016927.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types. {ECO:0000256|ARBA:ARBA00037319}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; H2MEC2; -.
DR STRING; 8090.ENSORLP00000016927; -.
DR Ensembl; ENSORLT00000016928.2; ENSORLP00000016927.2; ENSORLG00000013497.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158167; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR InParanoid; H2MEC2; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000013497; Expressed in gastrula and 3 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF84; CADHERIN-20; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..792
FT /note="Cadherin-20"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017396267"
FT TRANSMEM 609..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 154..262
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 263..377
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 378..482
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 482..604
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 792 AA; 88091 MW; 3A2D3697311FE14A CRC64;
MRTQLDLRLA VSRWVPLTLL MVLPHSFVAE PAEGDPGGSA LLQRVKRGWV WNQFFVLEEY
TGLEPLYIGK LHSDMDKGDG SIRYILTGEG AGTTFTIDDS TGDIHAIQRL DREVKSQYVL
RAQARNRLTD MPLEPESEFI VKIQDINDNE PKFLDGPYQA TVPEMSKVGT PVIQLTATDA
DDPTYGNSAR VVYSILEGQP YFSVDAKTGM VRVSLADMDR ETRENYTVVI QAKDMGGQLG
GLAGTTTINI TLSDVNDNAP VFDQRLYQMS VLESAPMGSV VGRIWAKDRD VGVNAEMKYR
IIDGDGRDTF DISTDPTNRF GIIMVKKLLD FEKKPSYTLK VEGVNTHPDL TFQNPGPFKD
VTIVHVSVED VDEPPLFDSA AYYMELPEDA EIGTVVRTVT ARDPDAANNT VRYSIEKTSD
PDKFFYIELT SGSLMTVRSL DREEISWHNI TVLAMEMNNP SQISSVSVAV KVLDVNDNPP
SLTHYLETYV CENAKAGQLV ETVTAVDPDE PPAGQHFHYS LAPEAANNPN FTLRDNQDNT
AWILTRRSSW SQKDQTVFYL PIFISDDEQP VQTSTSTLTV RVCSCDHEGN AMSCNAEAYS
LPASLSRGAL IAILACIFVL LVMILLMLSL RSHWKKPYLC DEEENIHENI VRYDDEGGGE
EDTEAFDIAA MWNPREVHHR GKTRQDMLPE IESLSRYVPQ ACVVGGRGDG NVHGYVLAKL
LEADGDPCAP PYDSLQTYAY EGDGSIAESL SSLQSGNSNA DHEYDYLNDW GPRFKKLAEM
YGVVETSSPP VW
//