ID H2MEE5_ORYLA Unreviewed; 660 AA.
AC H2MEE5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Heat shock cognate 70 {ECO:0000313|Ensembl:ENSORLP00000016951.2};
GN Name=hsc70 {ECO:0000313|Ensembl:ENSORLP00000016951.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016951.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016951.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016951.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016951.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016951.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR AlphaFoldDB; H2MEE5; -.
DR Ensembl; ENSORLT00000016952.2; ENSORLP00000016951.2; ENSORLG00000006386.2.
DR GeneTree; ENSGT00950000183206; -.
DR HOGENOM; CLU_005965_3_1_1; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000006386; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF484; HEAT SHOCK COGNATE 70; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT REGION 630..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 72707 MW; 72B99231AC6B049A CRC64;
MNDLCSRFLE VLDCEIDTFW SFSLGIDLGT TYSCVGIFQH GKVEIIANDQ GNRTTPSYVA
FTDTERLIGD AAKNQVAMNP ANTVFDAKRL IGRKFDDAVV QSDMKHWPFK VVNDSSKPKV
EVEYKGEIKT FYPEEISSMV LTKMKEISEA YLGKSVTNAV ITVPAYFNDS QRQATKDAGT
IAGLNVLRII NEPTAAAIAY GLDKKVGGER NVLIFDLGGG TFDVSILTIE DGIFEVKATA
GDTHLGGEDF DNRMVNHFIT EFKRKFKKEI TNNKRAVRRL RTACERAKRT LSSSTQASIE
IDSLYEGTDF YTSITRARFE ELNADLFRGT IEPVEKALRD AKMDKSQIHD VVLVGGSTRI
PKIQKLLQDL FNGRDLNKSI NPDEAVAYGA AVQAAILAGD KSENVQDLLL LDVTPLSLGI
ETAGGVMTVL IKRNTTIPTK QTQTFTTYSD NQPGVLIQVY EGERAMTKDN NILGKFELTG
IPPAPRGVPQ IEVTFDIDAN GILNVSAVDK STGKENKITI TNDKGRLSKE DIERMVQEAE
QFKAEDESQR DKITAKNSLE SLAFNMKSTV DDEKLQDKIS SEDKKTIVDK CNEIIAWLDK
NQMAEKDEYE HQQKELEKVC NPIISKLYQG GMPGGMPGGT PGGFSGGAGA SSGPTIEEVD
//
