ID H2MEN7_ORYLA Unreviewed; 1252 AA.
AC H2MEN7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Myosin X, like 1 {ECO:0008006|Google:ProtNLM};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017048.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017048.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017048.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017048.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017048.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; H2MEN7; -.
DR STRING; 8090.ENSORLP00000017048; -.
DR Ensembl; ENSORLT00000017049.2; ENSORLP00000017048.2; ENSORLG00000013589.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000159764; -.
DR HOGENOM; CLU_001626_1_0_1; -.
DR InParanoid; H2MEN7; -.
DR TreeFam; TF316834; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000013589; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0044295; C:axonal growth cone; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0048675; P:axon extension; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF9; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Myosin {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..74
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 401..499
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 581..693
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 731..890
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 895..1237
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 899..944
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 139..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1252 AA; 144028 MW; B8304132DDA07314 CRC64;
MLETVKIRRA GFPVRRTFKD FFSRRVALHL MGDDKKRTTD LLLKYDKTKK EWQLGKTKVF
MKESLEQRLE KDRDEVRRQA AMIIRAHLLT FSAKKHFKQV RAAVITLQKH LRRHIQRRRF
VKQRKAVLVL QKHRRGQVAR SRVRKLREEK KKKEEEQKKK EEEIKKTGEA KQEEAKDDAE
KTEDTSDDQV RQMEEILQLE REIERLQKKR EDEVSQLCES SKQELQLRRD AELKRMKKEA
SRKATELIDL LNFGGVDPSL GAAEAKPAAE NSPKKASAAA GASKEEEVDE GFHAEEECIP
LPDFPPPAES DVPIDQDIFA HLPPPPPAFA EGTVPPAPPP PPALPTDANP YNSVIVTLLN
GNGPPYFHGY LYMKAGLMIP WRRRWCVLKD ETFMWFRSKQ ESLKSGWLYK KGGGLSTLSR
RNWKMRWFVL RDSKLMYYEN DSEEKLKGTI DIKAAKEIVD NHEKENALNI VTDERTYQVF
AESPEDASGW FKVLSKVRVC TPEQLLDMSH EQANPKNAVG TLDVGLIDSV CASDNPDRPN
SFVIITANRV IHCNSDTPEE MHHWISLLQK PKGDARVDGQ EFLVRGWLQK EMKTNSKSTS
LKLKKRWFVL THNSLDYYKS SERNSSKMGT LVLNSLCSVI QPDEALSFRD YLKITVFSGL
NYLMYGRKHS YRLYTKMLNE AMRWTAAIQG VIDSKTPIET PTLQLIRDIK ENSVNPEIVE
QMYRRNPILR YTQHPLHSPL LPLPYGEVTS LQRQQGYASL QDEAVRVFNS LQEMETLADT
VPIIQGILQT CQDLRPLRDE VYCQVIKQTN HVPQPNSPAN LAHWHLLTCM SCTFLPGRAI
LRYLRFHLKR VRERYPGTEI ERYASFVGES LKKTKTREFV PSQEEIAALL VRQEMSTTVY
CHGGGSCKIS INSHTTAGEV VEKLIRGLAM EDSKNLFSLF EHNSFIDRAL ESRVIVADVL
AKFERLAGSE EEEEEGEWKL YFKLYCFLDV ESMPKEGVEF AFMFEQAHES LISGHFPASE
ETLQHLAALR LQYLHGDGAG RVGWSLGSVY PIGRLRNRIL HSTKPGVGTE KRKTPSFLDG
TLRRSFKTGS LKKQKVEEEQ MLEMWVKEET SATRTSVLEK WTRLQGMPQH QAMLKYMSII
KEWPGYGSTL FDVECKEGGF PHDLWLGVSA DNVSVYKRGE PKPLETFQYE HITFFGASQP
CTYKIIVDER EMFFETSLVG EITKIMRAYI NMMVKKRCSI MSVTSVGSSW AR
//
