ID H2MFA8_ORYLA Unreviewed; 796 AA.
AC H2MFA8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Cadherin 18 {ECO:0000313|Ensembl:ENSORLP00000017280.1};
GN Name=CDH18 {ECO:0000313|Ensembl:ENSORLP00000017280.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017280.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017280.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017280.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017280.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017280.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR RefSeq; XP_004081245.1; XM_004081197.2.
DR STRING; 8090.ENSORLP00000030444; -.
DR Ensembl; ENSORLT00000017281.2; ENSORLP00000017280.1; ENSORLG00000013779.2.
DR Ensembl; ENSORLT00000038412.1; ENSORLP00000030444.1; ENSORLG00000013779.2.
DR Ensembl; ENSORLT00000044151.1; ENSORLP00000036182.1; ENSORLG00000013779.2.
DR GeneID; 101174782; -.
DR KEGG; ola:101174782; -.
DR CTD; 1016; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000157512; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR OMA; RTMQDVY; -.
DR OrthoDB; 3667774at2759; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000013779; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF106; CADHERIN-18; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..796
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197793"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 161..269
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 270..384
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 385..489
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 489..606
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 796 AA; 88150 MW; 2AB2BF9A498F7DCF CRC64;
MRIPMTCCLC PFLVCLCFIQ RCYGASHHVP TKVPSKNQTK LANGETEVHH RPKRGWIWNQ
FFVLEEHMGP DAQYVGKLHS NSDKGDGSVR YILSGEGAGT IFIIDEVTGD IHATKSLDRE
RKAHYVLHAQ ALDRNTEEAL EPKSEFIIKV QDINDNAPKF PDGPFEATVP EMSEVGTSVL
QVTATDSDDP TYGNSAKIVY SILQGQPYFS VDPKTGIIRT ALPNMDREAR EHYTVVIQAK
DMAGQVGGLS GSTTINITLT DVNDNPPKFP QKNYQVLVLE SAEVGTPVGK LKANDDDLGT
NADIKYTIIN SEGANMFSIA TNRDTKEGIV SLKKPLNYER KKTYTLHIEG LNTHADPRFT
YLGPFKDTAT LKISVGDVDE APVFSMDYYI LDVYENSPSG TEVGTVTARD PDGDNKPVRY
ELDSKEEEES YFRIDAKSGV IRTTQPLDRE DTPWHNITVV ASEVGNPVLF SHVPVTVQVL
DTNDNPPEVA ADEEVIVCES SRPGQVIQTV RAVDKDDFAN GQRFSFALPS QLPVNPNFTL
KDNEDSTASI IARRRRFSHL TQELYELPIV VWDGGEPSLT GTSTLTLRVC PCQRHGRIRM
CQGEAFLSSA GLSTGALIAI LLCIIILLAI VVLFITLRRS KKEPLIISEE DIRENVVTYD
DEGGGEEDTE AFDIVALRNP AAAEELKFRR DIRPEARSQC GFAHGQRSPS VELDEVDVHK
FIKQRLVEAD MDASVPPYDS LQTYAYEGQG SPAGTISPLD SLGVQSEQEY NYLDDWGPEF
QKLAELYGEA ESDVTT
//
