ID H2MFK1_ORYLA Unreviewed; 776 AA.
AC H2MFK1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=GIT ArfGAP 1 {ECO:0000313|Ensembl:ENSORLP00000017375.2};
GN Name=GIT1 {ECO:0000313|Ensembl:ENSORLP00000017375.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017375.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017375.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017375.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017375.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017375.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004075960.1; XM_004075912.2.
DR AlphaFoldDB; H2MFK1; -.
DR Ensembl; ENSORLT00000017376.2; ENSORLP00000017375.2; ENSORLG00000013855.2.
DR GeneID; 101173241; -.
DR KEGG; ola:101173241; -.
DR CTD; 28964; -.
DR eggNOG; KOG0818; Eukaryota.
DR GeneTree; ENSGT00940000159604; -.
DR HOGENOM; CLU_009739_0_0_1; -.
DR OrthoDB; 2877020at2759; -.
DR TreeFam; TF317762; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000013855; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF1; ARF GTPASE-ACTIVATING PROTEIN GIT1; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..124
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 166..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 377..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 429..463
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 391..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 84187 MW; C2489B4DD9673015 CRC64;
MSRKLQRTEV CADCSAPDPG WTSINRGVLI CDECCSVHRS LGRHISIVKH LRHSGWPPTL
LQMVQTLASN GANSIWEHSL LDPAQVQSGR RKPNPQDKVH PTKSEFIRAK YQMLAFVHKL
PCRDDDGVTT KDLSKQLHSS VRTGSLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQI
LQAELLVVYG ADPGAPDING RTPMDYARQA GHIELAERLV ECQYELTDRL AFYLCGRRPD
HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LNNRLFEELA MDVYDEVDRR ENDAVWLTTQ
NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSD AKRRQQGKGL
SPTDPLDLAI DDDQHDYDSV ASDEDTDSEL ATHNNNNTQR SNRAKSMDSS DLSDGPITLQ
EYLEVKKALA SSEAKVQQLM KVNNNLSEEL RRLQKEITRM QTENSVLRGC QQAGGAAGHG
LGGPGGGGGG GGGGGHWPGG GNQVDGGGSA GPGMVSPSLF VPSSTASHSH PHWRERQAFS
MYVPGAVPGP IAHGPPALDS LAARLQPLNT PSVRKGGTGG AVTYGGQPLS GSTEVGRYMV
PKPEKHGSGT DSDYDNTHMY DPSLSVGRSS EEESRGESED GGGGEGGEPD PTLPCTEDVI
LKTEQVTKNI QELLRAAQEF KHDSFVPCSE KIHSAVTEMA SLFPKRPALD AVHCSLRLLA
SSASRLQVEC RKAVPSESGA PAVDYQLLTQ QVIQCAYDIA KAAKQLVTIT TREKKQ
//
