ID H2MG76_ORYLA Unreviewed; 1406 AA.
AC H2MG76;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
GN Name=serpinc1 {ECO:0000313|Ensembl:ENSORLP00000017607.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017607.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017607.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017607.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017607.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017607.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR STRING; 8090.ENSORLP00000017607; -.
DR Ensembl; ENSORLT00000017608.2; ENSORLP00000017607.2; ENSORLG00000028536.1.
DR eggNOG; ENOG502QVJ5; Eukaryota.
DR GeneTree; ENSGT00940000157967; -.
DR HOGENOM; CLU_304324_0_0_1; -.
DR InParanoid; H2MG76; -.
DR TreeFam; TF331178; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000028536; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0051298; P:centrosome duplication; IBA:GO_Central.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0071539; P:protein localization to centrosome; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR InterPro; IPR026123; Sil.
DR PANTHER; PTHR15128:SF0; SCL-INTERRUPTING LOCUS PROTEIN; 1.
DR PANTHER; PTHR15128; TAL1 SCL INTERRUPTING LOCUS; 1.
DR Pfam; PF00079; Serpin; 1.
DR Pfam; PF15253; STIL_N; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1033..1403
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT REGION 381..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1011
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1406 AA; 154779 MW; D4D14904D67F9C84 CRC64;
MSCPVKLQAL PSSVFDKIVT PENMRVRSSV SSLSQLSFPK SRSALWDGTP AGEKLNLQLC
SHRKLHLVLQ EKTLRLAQRH ARHSNKPSLH FFLLGSVSVD ADEEGITVTL DRFDPGRDQG
GGSGPVPSTV LPGDVAVPCL FSDRPEPMPE AVIHSETEFH QCFKVLQHAV SCRQTLDLSQ
LLKIRARIIC SHQSDAAVFS LSWLAVCPAM SVDIQPVRPL PIIPTALLRS LTGAGRPAQH
SSHQRGFLTM DQTRKLVLLL ESDPKASSLP LVGLWMSGIT HVYNPQVWVC SLRFMFGASL
QDRVLSESGC FLLVVFGSTH RAPQFFQCRG SRTGPQLECQ ILTSTQSVTL YQQVVPADGR
VLRCELGSEV HSRQAEVFRA AQRSFSSSPP PAAGLSVSDQ DSGVEDEDLS PRPSPNPHLP
APQTRRVQPS VPELSLLVDG SFSFNQNKEP DPAPRPFPLE SKTTAPATSS LASTSAPHLH
STPNSNIHQP CTCCSTHAYS CTSIHPSPTL PPAAPTPSHL QTSPKVSSAP SPSTPHQKPV
CSRPVFQRPP AYQLTPPPME SNCPRPQSHQ QTHPPPNHYS AVPQTSSHHH SPPPLHQPLP
GPSLLSSNQK ALHPSPCSPP PPAFTSQHVF PSHSIPAPPL PSSSCSNSVA PPSHTSPPSP
CPAAPLSCLP PAPPCHCCPH PPLSNPALGA DSLSPSWLPR PACVNRCCDL MSGVAPSDAY
QLLLHQDRQL RLLQAQVQML LEAQKKLQVN TQTSRSTTSV AVETGASLFW GSGPEQPPSH
RDNPSSPPKL PTPSSSSSSS PTSSHDPCER RAVGGAENGD ITSQEAPSSP LVQHSLSGLQ
SPVLGESVSM YAPRDEQQSF YKNLMTQLHS RLQESDDKQE VEEDSRRKSQ PSSDHSHSSS
SASSSSSQKK KLQLRERDPV VTATVRQLQQ LGVEVDEADL IESDKNRLKA VQSARMRATH
WLLVLAFLPS IVLAQHVDIC NAKPKDLPLE PRCSYRSPDL ETPEDHTPEP KVVPESTNPR
VWELSKANSH FALSFYKHLA VSRKTEENIF MSPISISTAF AMTKLGACNR TLEQIMKVFQ
FDTIKEKTSD QVHFFFAKLN CRLYRKKDET TELVSANRLF GEKSLFFNET FQNITEMVYG
AKLLPLNFKM YPEQARITIN DWISNKTENR IKDTLPSGVL DSNTVLVLVN TIYFKGQWKK
KFDKKAVFSS DFQVSSSHNC QVNMMFQESK FKYKYFPDDE VQVLEMPYIG DDITMVIILP
SRNTPLNQVE ESLNLKKLNN WLDQMTETSV SVSIPRFKVE DKFNLKEVLQ EIGLTDLFSA
ENASLPGILE DDSDGLFISD AYHKAFLEVN EEGSEAAAAT VVLAVGRSFN PYREVFQADR
PFLLFIREST INTLLFSGRV VNPCDQ
//
