ID H2MGW7_ORYLA Unreviewed; 1043 AA.
AC H2MGW7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=gucy2ca {ECO:0000313|Ensembl:ENSORLP00000017861.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017861.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017861.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017861.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017861.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017861.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC Evidence={ECO:0000256|ARBA:ARBA00036920};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; H2MGW7; -.
DR Ensembl; ENSORLT00000017862.2; ENSORLP00000017861.2; ENSORLG00000014236.2.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000155955; -.
DR HOGENOM; CLU_001072_1_3_1; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000014236; Expressed in intestine and 6 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF347; GUANYLYL CYCLASE C; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1043
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017273581"
FT TRANSMEM 399..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..708
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 783..913
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1043 AA; 119720 MW; 648158E23CF33C98 CRC64;
MYGLQSLLFL GTLTMLVSND MLDDCLESNP RYTMNVVLLE DNTYEWSRPF VQEAVEGAIK
KDAEENRKAG LNFTLTANYN WFNTNLYNRQ GCGSSTCEGV AILKKLHVEV GCVMLGPSCT
FATFQLVDME IGLSLSIPVI SAGSFGLSCD YKPKLTRILP PARKVSDSLV YFFNEKNMLK
PIWEKAYVYK KSNNVTEDCF WYNNALEAPS AHFASSKKRE MLRGEEELKK ALTSKYRFSN
IFILCGSVDD IVSIKGLAKQ FHEDTIFILI DLYNPEYYIN TTSLAPMRDV LVVTLPPRNY
VNESNSTFNN TINDYVAGYH DSALLFGEVL RRKMLSQHVP LSDTPFGNIS FEGMAGNYVL
DEYGDRDVNF TFIYTSAQTS KDVNHLYLCL LADLSTQDII VIVLGVSVVV VTAIALIFYS
VWIFSKPLRL CPLGFHLTTF NIYDLFTEQI DEDKRKDSTF FSHRGRYDKK PVVLKELKHP
DEDFTEEQKI ELNTLLRIDY YNLTKFYGTV KFEYGVFGVF ELCQRGSLRY ILNDRISYPD
ETFMDMEFKI SVMYDIAKGM SYLHTSNIPV HGRLKSTNCE VDNRMVVKIT DFGCHTILKP
AKDLWTAPEH LRKDGVSQKG DVYSYAIIAH EIVTRKPPFY TQYCSDSAEK MYRVQYPRNN
NFFRPELNFE GASDRETEVY MLIKNCWDED PERRPDFKKI ELTLGKIFSN LHNQATETYM
DNLIRRLQMY SRTLENLVEE RTALYKAERD RADHLNFMLL PGPVVRSLKE TGRVEPELFE
EVTIYFSDIV GFTTLCHYST PMEVVDMLNN IYKNFDSILD HHDVYKVETI GDAYMVASGL
PNRNGDRHAV DIAHMALDIL SFVGTFELQH LPGIPLWIRI GVHSGPCAAG VVGNKMPRYC
LFGDTVNTAS RMESTGLPLR IHVSQSTIKI LQRTPCKFEF EQRGETYLKG KGKEMTYWLT
GVTGGNYNLP TPPTAENFQR LQQDLADMII SSLEKREGGK ETIEKRKTLS TRIRWKDRNN
SFQKESPPEY FHLAVTENPS TYL
//
