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Database: UniProt
Entry: H2MHJ5_ORYLA
LinkDB: H2MHJ5_ORYLA
Original site: H2MHJ5_ORYLA 
ID   H2MHJ5_ORYLA            Unreviewed;       840 AA.
AC   H2MHJ5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   23-MAY-2018, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101156445 {ECO:0000313|Ensembl:ENSORLP00000018104};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018104, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000018104, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018104,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000018104}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018104};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; BAAF04058827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04058828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04058829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004080776.1; XM_004080728.2.
DR   Ensembl; ENSORLT00000018105; ENSORLP00000018104; ENSORLG00000014447.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000001038; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    560       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    774    796       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   840 AA;  95930 MW;  271FBA05568877DC CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKVGIPMV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILHRTQQFFD EMEDPNLLEE SSALMEGSER GRGAPLRLGF VAGVISRERI
     PTFERMLWRV CRGNVFLRKA EIEDPLEDPT TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RASLYPCPET PQERKEMLAG VNSRIDDLQM VLNQTEDHRQ RVLQAASKTM RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TERSGSTVPS ILNRMQTKQT
     PPTFNKTNKF TSGFQNIVDA YGIGNYREIN PAPYTIITFP FLFAVMFGDM GHGLLMLCAA
     LYLVLRESRI LAQKIDNEMF NMVFAGRYII LLMGVFSVYT GVIYNDCFSK SLNMFGSGWS
     VRPMFSAKGA NWTFTTLKEN TVLQLDPAVP GVFNGPYPLG IDPVWNIATN KLTFLNSFKM
     KMSVILGVIH MLFGVSLSLF NHLYFKKPLN IFLGFIPEIV FMFSLFGYLV LLVFYKWTAY
     DAFTSKDAPS LLIHFINMCL FNYNDPTNKP LYRGQMGIQI LLVLIALACV PCMLIVKTMV
     LRRQHLWKKH LGTQKFGGVR VGNGPTEDEA GIMDHDQLSQ HSEEGDEHSE EEPFDFGDVA
     VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWS MVMHLGLSSR SGGGFFGLSI
     IFAAFAMLTV AILLIMEGLS AFLHALRLHW VEFQNKFYTG QGFKFVPFSF ESILEGRFDE
//
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