ID H2MK98_ORYLA Unreviewed; 493 AA.
AC H2MK98;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Fibronectin type III and SPRY domain-containing protein 1 {ECO:0000256|ARBA:ARBA00039546};
GN Name=fsd1 {ECO:0000313|Ensembl:ENSORLP00000019107.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019107.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000019107.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019107.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000019107.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019107.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in microtubule organization and
CC stabilization. {ECO:0000256|ARBA:ARBA00037674}.
CC -!- SUBUNIT: Oligomerization is required for binding to microtubules.
CC {ECO:0000256|ARBA:ARBA00038555}.
CC -!- SUBCELLULAR LOCATION: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|ARBA:ARBA00004300}.
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DR RefSeq; XP_004068247.1; XM_004068199.2.
DR AlphaFoldDB; H2MK98; -.
DR STRING; 8090.ENSORLP00000019107; -.
DR Ensembl; ENSORLT00000019108.2; ENSORLP00000019107.2; ENSORLG00000015253.2.
DR GeneID; 101159661; -.
DR KEGG; ola:101159661; -.
DR CTD; 79187; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000159440; -.
DR HOGENOM; CLU_013137_19_1_1; -.
DR InParanoid; H2MK98; -.
DR OrthoDB; 5386672at2759; -.
DR TreeFam; TF333654; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000015253; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0051302; P:regulation of cell division; IBA:GO_Central.
DR GO; GO:0060236; P:regulation of mitotic spindle organization; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF4; FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 105..162
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT DOMAIN 164..268
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 279..474
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 303..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55497 MW; 0431F5EF4EE877D4 CRC64;
MGDQKESLRK ITHTLAVKNE EISNFICSLK QSLDNLETNS NRVQEDLESE FSCLHAVLDE
MKESMLTRIK QERASRTYEL QSQLSACTKA LESSEELLEL ANQTLCSSQT DGFSQAAKDI
KDSVTMAPAF RLSLKTKASD NMSHLMVDFS QERELLQALK FLPVPATPEI QVSECQVCDN
TVTVSWTIPE PDSKIDHYIL EYRRTNHEGP PRVREDYPWM VVEGIRQMEH TVTGLRFDTR
YMTFRVRACN KAVAGDFSEP VTLETHAFNF KLDSGSAHQN LKVEDLSVEW DSCGGKVQDI
RKEKNRTNSP MHSPARSALM SPKRAPTARP GRDRFTAESY TVLADTMIDA GQQYWEVRFD
KESKAFAVGV ALRSLGRFDQ LGKSSASWCI HLNNWLQQSL TAKHNNKART LDCSIPGSIG
VYVNYEEGIL SFYNAKTKQL MHTFKTKFQQ PVIPAFMVWN GSFSVVTGLQ VPTVVQSGQR
KNSGTSSSNA SLT
//