ID H2MLS7_ORYLA Unreviewed; 374 AA.
AC H2MLS7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Nucleoside diphosphate kinase 7 {ECO:0000256|PIRNR:PIRNR036503};
DE EC=2.7.4.6 {ECO:0000256|PIRNR:PIRNR036503};
GN Name=nme7 {ECO:0000313|Ensembl:ENSORLP00000019661.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019661.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000019661.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019661.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000019661.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019661.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Major role in the synthesis of nucleoside triphosphates other
CC than ATP. {ECO:0000256|ARBA:ARBA00003465}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-
CC deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316,
CC ChEBI:CHEBI:456216; EC=2.7.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR036503};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRNR:PIRNR036503};
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC ECO:0000256|PIRNR:PIRNR036503, ECO:0000256|RuleBase:RU004011}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011472730.1; XM_011474428.1.
DR AlphaFoldDB; H2MLS7; -.
DR STRING; 8090.ENSORLP00000019661; -.
DR Ensembl; ENSORLT00000019662.2; ENSORLP00000019661.2; ENSORLG00000015702.2.
DR eggNOG; KOG0888; Eukaryota.
DR GeneTree; ENSGT00940000158946; -.
DR HOGENOM; CLU_2432683_0_0_1; -.
DR InParanoid; H2MLS7; -.
DR OrthoDB; 46345at2759; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000015702; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04412; NDPk7B; 1.
DR Gene3D; 2.30.29.170; -; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 2.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR011410; NDPK7.
DR InterPro; IPR037993; NDPk7B.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR PANTHER; PTHR43109; NUCLEOSIDE DIPHOSPHATE KINASE 7; 1.
DR PANTHER; PTHR43109:SF2; NUCLEOSIDE DIPHOSPHATE KINASE 7; 1.
DR Pfam; PF00334; NDK; 2.
DR PIRSF; PIRSF036503; NDK7; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00676; DM10; 1.
DR SMART; SM00562; NDK; 2.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 2.
DR PROSITE; PS51336; DM10; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR036503, ECO:0000256|PIRSR:PIRSR036503-
KW 51}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|PIRNR:PIRNR036503};
KW Magnesium {ECO:0000256|PIRNR:PIRNR036503};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR036503};
KW Nucleotide metabolism {ECO:0000256|PIRNR:PIRNR036503};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036503,
KW ECO:0000256|PIRSR:PIRSR036503-51}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|PIRNR:PIRNR036503}.
FT DOMAIN 1..89
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT ACT_SITE 204
FT /note="Pros-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-50"
FT BINDING 97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 143
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 191
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
SQ SEQUENCE 374 AA; 42180 MW; 8CE376558D58BB00 CRC64;
MEDRYAFLAE WFDPIAALMR RFQLFYYPND GSMEMFDVKN QRVFLKRIKY DDIHPRDLFV
GNRVNVFSRQ LNLIDYGDQY TRNKLGSKKE RTLALIKPDV VTKIGDVMEL VYSSNLIVTK
AKMTRLSWSQ AADFYMEHQS KSFFNNLVQF MSSGPVVAME IMGDEATSVW RKLLGPADSA
AARREAPQSI RAHFGTDGLQ NVGHGSESLD AAARELEFFF PSAIGHGPSN TATFTDCTCC
IIKPHAVSDG LTGKILNSIS AAGFEISALQ MFNMERVNAE EFYEVYKGVV LEYPGMVTEL
CSGPCMALEI RGTDTPKTFR EFCGPADPEI ARHLRPNTLR ALYGKDKVRN AVHCTDLPED
GVLEVQYFFK ILDT
//
