ID H2MME3_ORYLA Unreviewed; 746 AA.
AC H2MME3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cullin 3 {ECO:0000313|Ensembl:ENSORLP00000019883.2};
GN Name=CUL3 {ECO:0000313|Ensembl:ENSORLP00000019883.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019883.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000019883.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019883.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000019883.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019883.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; H2MME3; -.
DR Ensembl; ENSORLT00000019884.2; ENSORLP00000019883.2; ENSORLG00000015875.2.
DR eggNOG; KOG2166; Eukaryota.
DR GeneTree; ENSGT00940000155066; -.
DR HOGENOM; CLU_004747_7_1_1; -.
DR TreeFam; TF105858; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000015875; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 361..613
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 655..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 86339 MW; 6E5DE6D12DD79F60 CRC64;
MTMDEKYVNN IWDLLKSAIQ EIQRKNNSGL SFEELYRNAY TMVLHKHGER LYTGLREVVT
EHLINKVRED VLNSLNNNFL QTLNQAWNDH QTAMVMIRDI LMYMDRVYVQ QNNVENVYNL
GLIIFRDQVV RYGCIRDHLR QTLLDMIARE RKGEVVDRGA IRNASQMLMI LGLDGRSVYE
EDFEGPFLDM SAEFFQMESQ KFLAENSASV YIKKVEARIN EEIERVMHCL DKSTEEPIVK
VVERELISKH MKTIVEMENS GLVHMLKNSK TEDLACMYKL FSRVPNGLKT MCECMSSYLR
EQGKALVSEE GEGKNPVDYI QGLLDLKTRF DHFLIESFNN DRLFKQTIAG DFEYFLNLNS
RSPEYLSLFI DDKLKKGVKG LTEQEVESIL DKAMVLFRFM QEKDVFERYY KQHLGRRLLS
NKSVSDDSEK NMISKLKTEC GCQFTSKLEG MFRDMSISNT TMDEFRQHIQ TTSASLSGVD
LTVRVLTTGY WPTQSATPKC TIPPAPRHAF EVFRRFYLAK HSGRQLTLQH HMGGADLNAT
FYGAVKKEDG SEVGVGGAQV TGSNTRKHIL QVSTFQMTIL MLFNNIDKFN FEEIQQETDI
PERELVRALQ SLACGKPTQR VLTKEPKSKE IESGHVFTVN DQFTSKLHRV KIQTVAAKQG
ESDPERKETR QKVDDDRKHE IEAAIVRIMK SRKKMQHNVL VAEVTQQLRA RFLPSPVVIK
KRIEGLIERE YLARTPEDRK VYTYVA
//
