ID H2MMP4_ORYLA Unreviewed; 381 AA.
AC H2MMP4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
GN Name=LOC101157024 {ECO:0000313|Ensembl:ENSORLP00000019990.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019990.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000019990.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019990.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000019990.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019990.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000256|RuleBase:RU369013}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC protein {ECO:0000256|RuleBase:RU369013}.
CC -!- SIMILARITY: Belongs to the ERGIC family.
CC {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR AlphaFoldDB; H2MMP4; -.
DR STRING; 8090.ENSORLP00000019990; -.
DR Ensembl; ENSORLT00000019991.2; ENSORLP00000019990.2; ENSORLG00000015969.2.
DR eggNOG; KOG2667; Eukaryota.
DR GeneTree; ENSGT00530000063113; -.
DR HOGENOM; CLU_034705_4_1_1; -.
DR InParanoid; H2MMP4; -.
DR TreeFam; TF317192; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000015969; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR045888; Erv.
DR InterPro; IPR012936; Erv_C.
DR InterPro; IPR039542; Erv_N.
DR PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR PANTHER; PTHR10984:SF30; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2; 1.
DR Pfam; PF07970; COPIIcoated_ERV; 1.
DR Pfam; PF13850; ERGIC_N; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU369013};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU369013}.
FT DOMAIN 13..99
FT /note="Endoplasmic reticulum vesicle transporter N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13850"
FT DOMAIN 164..340
FT /note="Endoplasmic reticulum vesicle transporter C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07970"
SQ SEQUENCE 381 AA; 43056 MW; E559C92FFAD2DE1D CRC64;
MRRLSRRKAL SLVKELDAFP KVSDSYVETS TSGGTVSLIA FSTMALLSVL EFFVYQDTWM
KYEYEVDKDF SSKLRINVDV TVAMRCQHVG ADILDLAETM ITSGGLQYEP VVFELTPKQR
EWQSTLHRIQ NRLREEHALQ EVLYKSLLKG APTALPPRDA VFMQSPDACR IHGDIYVNKV
AGNLHITTII ETFCFTGFVS KSRCGSSCCP PSSPLHAAAY NFSHRIDRLC FGEEIPGIIN
PLDGTEKITY DNNQMYQYFI TVVPTKLKTY KITADTHQFS VTERERVINH TAGSHGVSGI
FFKYDTSSLM VTVSEQHMPL WQFLVRLCGI IGGIYSTTGM LHSLIGFCFD IVCCRFNLGV
YRRREVSLQF LLRRLASGPS S
//
