ID H2MMQ7_ORYLA Unreviewed; 812 AA.
AC H2MMQ7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN Name=LOC101169531 {ECO:0000313|Ensembl:ENSORLP00000020003.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020003.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020003.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020003.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020003.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020003.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004069319.1; XM_004069271.2.
DR AlphaFoldDB; H2MMQ7; -.
DR STRING; 8090.ENSORLP00000020003; -.
DR Ensembl; ENSORLT00000020004.2; ENSORLP00000020003.2; ENSORLG00000015979.2.
DR GeneID; 101169531; -.
DR KEGG; ola:101169531; -.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_013596_0_0_1; -.
DR InParanoid; H2MMQ7; -.
DR OrthoDB; 5840at2759; -.
DR TreeFam; TF324918; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000015979; Expressed in animal zygote and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0016050; P:vesicle organization; IBA:GO_Central.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF41; SORTILIN-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..812
FT /note="VPS10 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017370680"
FT TRANSMEM 736..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..723
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 812 AA; 90335 MW; B88B8093BA5396C9 CRC64;
MIWVLCILSL GFIWPAAGRH ARNAEHLSGL KRFQRDFGGD DDDRSAVESS VLLSQSSAGP
NDQTCTPLLG VEAALLNHTS TFMFKVRTAG SLSLAWVGDG TGVLLVLTTF HAPFLLMRFG
QSNLYRSEDY GKTFRDVTDR INHTFIQSEF GISVSPDHSG KVLLTGDVSG FGRFRLFRSR
DFGLSFAQSD LPFEPLIQML FNPEDSNTLL TLSIRLDLWL SEDFGATWRK IHDSVCLVRW
SSRNTIYFTT SNNVSCSEKG MLELKKTLNY GRSFQTIATR VYSFALGGKF VFASIMTGTG
TERTIHVSVD GGGHWNMAQL PTATNQQFYS FLAANQDMIF MHVDDPGDTG IGTIYVSDDR
GIVFSKSLER HLYTTTGSDT DFTTISSLRG VYLTSILTED GVVETVITYD QGAKWQTLRR
PENSQCGSDT STNRANTCRL HIHASYSTTM KMNVPMLPLS QPNAVGLILA HGSLGDAEST
LFPDVYVSDD GGYTWMLALK GPHHYAILDS GGLLVAVEHT NALVNQIKFS TDEGQCWHTY
NFTNDPLHFS GMDSEPGSRS MNVSLWGYRN DFSKWVVVTI DFKKLLTRDC DDGDYVEWLA
HSADRSGSSD GCVLGYKETL LRLRKDSVCW NGRDFVVRRK PSPCLCTEVD YHCDFGFYRP
ENSSECVMQE EVKGRALEFC LNDTAEQLQT SGYRKIPGNQ CEGGFQPTRK ETDLGKICTS
DALHPNFLTD NSSLNAVAIA MVVIAILLTS ALAGVWLVKK YVCGGRFLVH RYSVMRESVE
ANKIEGVDDV DTQYMETAKA QFNEDSDQDL LD
//
