ID H2MNR7_ORYLA Unreviewed; 952 AA.
AC H2MNR7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=LOC101173475 {ECO:0000313|Ensembl:ENSORLP00000020373.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020373.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020373.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020373.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020373.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020373.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; H2MNR7; -.
DR STRING; 8090.ENSORLP00000020373; -.
DR Ensembl; ENSORLT00000020374.2; ENSORLP00000020373.2; ENSORLG00000016270.2.
DR eggNOG; KOG1480; Eukaryota.
DR GeneTree; ENSGT00950000182815; -.
DR InParanoid; H2MNR7; -.
DR OrthoDB; 2971005at2759; -.
DR TreeFam; TF316767; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000016270; Expressed in animal zygote and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 25..952
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025085489"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 153..235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..665
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 913..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 952 AA; 105093 MW; E99BDFC157C47608 CRC64;
MGTPTNPLLT SGLLLLGAVL SVFSKGVTQS DSLPSGHGTL PHFIQEPEDA YIVKSNPTKL
RCRATPALQI FFKCNGEWVH QNEHMSHEYK DLITGLKVRE VMINISRQQV EDFHGPEDYW
CLCVAWSHLG TSKSRKATVR IAYLRKNFEQ DPQGKEVPIN RMIVLHCRPP EGVPAVEVEW
LKNEELVSSM TDDNIDSRAD QNLIINEARL SDSGNYTCLA SNIVAKRRSA TATVIVFVNG
GWSLWTEWSP CNVPCGWGVQ KRSRTCTNPA PLNGGAFCEG MSVQKIPCNA LCPVDGGWDE
WSEWTLCNSL CGRHRTRECS SPAPRHRGKM CEGNSEATEN CTDGLCTQNR NLRHDVKPQS
MEGSNDVALY LCLGAGIIAV AFLVVVVMLY RKSHSEYGVD VIDSSALTRG CQSFNFKTTS
QGNPLLLNSS MRSDLTVGRT YSTPICFHES ADKELFDPLP DIAVKVQSSF MISLGVADHA
TFPDKVPAET YQRDLGCEYC STMERRKKDT LMFSRPIAVD KEQPRTSGVF GHQGGRLAVP
STGVSLLVPH GAVAEYMSCE VYMVINQGES SIETLEGCEI LLGPEVTYGP SNLDLFCPAA
VTVPHCAVVD KENWNIQLRR KTQDSKWEEV MLVDEESTSC FCLMDSTCCH LLLDQPGSYA
LVGEPLNQAA MKRLKLGVFG GLEASSTNYC LRVYCVDDTP HGFQRVVAAE RTRGGQLLEE
PKMLPFQANT FNLQVSIQDV PQFLWSIKPF TTCQEFSFSQ VWCSNQQPMH CTFALERFSP
ATAQLSCKIS VRQVKGHEQI LQVYTAVAEG EKESPPFFMQ TDCSVTSQTG PKAFKIPSSI
RERICATFDT ANAKGKDWQL LAQKLHLDRN LGYFAKQHSP SAVILSLWEV CHPDADDLDS
LANALEEIGK IHSCSSPEDQ DEDQSDAGHV DASSLCGPGG LTSEDSAADF TG
//