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Database: UniProt
Entry: H2MNR7_ORYLA
LinkDB: H2MNR7_ORYLA
Original site: H2MNR7_ORYLA 
ID   H2MNR7_ORYLA            Unreviewed;       952 AA.
AC   H2MNR7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN   Name=LOC101173475 {ECO:0000313|Ensembl:ENSORLP00000020373.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020373.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000020373.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020373.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000020373.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020373.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; H2MNR7; -.
DR   STRING; 8090.ENSORLP00000020373; -.
DR   Ensembl; ENSORLT00000020374.2; ENSORLP00000020373.2; ENSORLG00000016270.2.
DR   eggNOG; KOG1480; Eukaryota.
DR   GeneTree; ENSGT00950000182815; -.
DR   InParanoid; H2MNR7; -.
DR   OrthoDB; 2971005at2759; -.
DR   TreeFam; TF316767; -.
DR   Proteomes; UP000001038; Chromosome 9.
DR   Bgee; ENSORLG00000016270; Expressed in animal zygote and 5 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Signal {ECO:0000256|RuleBase:RU367033};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   CHAIN           25..952
FT                   /note="Netrin receptor UNC5"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT                   /id="PRO_5025085489"
FT   TRANSMEM        367..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          153..235
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          524..665
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   REGION          913..952
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        913..928
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   952 AA;  105093 MW;  E99BDFC157C47608 CRC64;
     MGTPTNPLLT SGLLLLGAVL SVFSKGVTQS DSLPSGHGTL PHFIQEPEDA YIVKSNPTKL
     RCRATPALQI FFKCNGEWVH QNEHMSHEYK DLITGLKVRE VMINISRQQV EDFHGPEDYW
     CLCVAWSHLG TSKSRKATVR IAYLRKNFEQ DPQGKEVPIN RMIVLHCRPP EGVPAVEVEW
     LKNEELVSSM TDDNIDSRAD QNLIINEARL SDSGNYTCLA SNIVAKRRSA TATVIVFVNG
     GWSLWTEWSP CNVPCGWGVQ KRSRTCTNPA PLNGGAFCEG MSVQKIPCNA LCPVDGGWDE
     WSEWTLCNSL CGRHRTRECS SPAPRHRGKM CEGNSEATEN CTDGLCTQNR NLRHDVKPQS
     MEGSNDVALY LCLGAGIIAV AFLVVVVMLY RKSHSEYGVD VIDSSALTRG CQSFNFKTTS
     QGNPLLLNSS MRSDLTVGRT YSTPICFHES ADKELFDPLP DIAVKVQSSF MISLGVADHA
     TFPDKVPAET YQRDLGCEYC STMERRKKDT LMFSRPIAVD KEQPRTSGVF GHQGGRLAVP
     STGVSLLVPH GAVAEYMSCE VYMVINQGES SIETLEGCEI LLGPEVTYGP SNLDLFCPAA
     VTVPHCAVVD KENWNIQLRR KTQDSKWEEV MLVDEESTSC FCLMDSTCCH LLLDQPGSYA
     LVGEPLNQAA MKRLKLGVFG GLEASSTNYC LRVYCVDDTP HGFQRVVAAE RTRGGQLLEE
     PKMLPFQANT FNLQVSIQDV PQFLWSIKPF TTCQEFSFSQ VWCSNQQPMH CTFALERFSP
     ATAQLSCKIS VRQVKGHEQI LQVYTAVAEG EKESPPFFMQ TDCSVTSQTG PKAFKIPSSI
     RERICATFDT ANAKGKDWQL LAQKLHLDRN LGYFAKQHSP SAVILSLWEV CHPDADDLDS
     LANALEEIGK IHSCSSPEDQ DEDQSDAGHV DASSLCGPGG LTSEDSAADF TG
//
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