ID H2MNS1_ORYLA Unreviewed; 424 AA.
AC H2MNS1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Autoimmune regulator {ECO:0000313|Ensembl:ENSORLP00000020378.2};
GN Name=aire {ECO:0000313|Ensembl:ENSORLP00000020378.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020378.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020378.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020378.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020378.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020378.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2MNS1; -.
DR STRING; 8090.ENSORLP00000020378; -.
DR Ensembl; ENSORLT00000020379.2; ENSORLP00000020378.2; ENSORLG00000016279.2.
DR eggNOG; KOG0383; Eukaryota.
DR GeneTree; ENSGT00940000161104; -.
DR HOGENOM; CLU_042233_1_0_1; -.
DR InParanoid; H2MNS1; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000016279; Expressed in sexually immature organism and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0002509; P:central tolerance induction to self antigen; IBA:GO_Central.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0045060; P:negative thymic T cell selection; IBA:GO_Central.
DR GO; GO:0002458; P:peripheral T cell tolerance induction; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:2000410; P:regulation of thymocyte migration; IBA:GO_Central.
DR GO; GO:0097536; P:thymus epithelium morphogenesis; IBA:GO_Central.
DR CDD; cd15539; PHD1_AIRE; 1.
DR CDD; cd15540; PHD2_AIRE; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR042580; AIRE_PHD2.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24102; PHD FINGER PROTEIN; 1.
DR PANTHER; PTHR24102:SF28; PHD-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 196..243
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 49..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 46263 MW; B18A5AA28CCFB87C CRC64;
MYSMLSWVLE RSKSTIQSFW SNLSKDYNTE SYPKLQTLLA NLHSRSKAAS FKTENGSSGV
SHSKKRSHEN SETNSRYLAK TSNAGSKVKL YRVKTEAPNL KLPTGNSKQG GPSSFQGGKP
LASSTDSRVS SEKKEILQIK QEHSFGGSNR TNIKVGEGFY SSGLKEEMNA EMPESATNAF
RHQGETTTSM VIHCNDDECA VCKDGGELIC CDGCPRAFHL TCLNPPLISI PSGSWQCERC
RGFTVKSEKA LLPLEALSGQ LQQENKASSD SITDISFYSS NSSALPPSMS ASSSKAQCSG
EELMVIREEC GICHLGGGDL LHCLQCFQGF HVRCHFSKGS SICLSCSRLW SSSAEKEAEL
RGLQLAPAAQ NTCTHDQSTS ISEAMVKRDD VDSMMTEQNS IDGILQWALQ SFSRPLQDSQ
GCFQ
//
