ID H2MPD8_ORYLA Unreviewed; 1165 AA.
AC H2MPD8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Deleted in malignant brain tumors 1 protein-like {ECO:0008006|Google:ProtNLM};
GN Name=LOC101164448 {ECO:0000313|Ensembl:ENSORLP00000020597.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020597.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020597.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020597.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020597.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020597.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; H2MPD8; -.
DR STRING; 8090.ENSORLP00000020597; -.
DR Ensembl; ENSORLT00000020598.2; ENSORLP00000020597.2; ENSORLG00000016446.2.
DR GeneTree; ENSGT00940000166622; -.
DR HOGENOM; CLU_1708278_0_0_1; -.
DR InParanoid; H2MPD8; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000016446; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.10.250.10; SRCR-like domain; 8.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF15; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 8.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00409; IG; 2.
DR SMART; SM00202; SR; 8.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56487; SRCR-like; 8.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00420; SRCR_1; 2.
DR PROSITE; PS50287; SRCR_2; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1057..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..24
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 27..121
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 126..226
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 229..323
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 328..428
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 431..528
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 531..631
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 636..737
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 740..840
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 944..1026
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1101..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 94..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 151..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 164..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 195..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 296..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 353..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 366..427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 397..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 497..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 556..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 569..630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 600..610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 705..715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 765..829
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 778..839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 809..819
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1165 AA; 126161 MW; 5ACA08DAC15B123F CRC64;
MKCPHKPIGI NNCGHGEDAG VVCAENVRVM NGSNRCNGRV EVYQDGHWKR VCSSDWGKEE
AEVVCQEIKC GTPLLNVMQN FGEAQGLAGI KTSCVGNETS ISNCQLQEFK ESCIDATVVC
SNSKPIRLIN GTDRCSGRVE VYYEGQWGTV CDDKWGMQEA AVACREMNCG NPMAIKTKAF
FGRGSDTVWL DDIECLGHEK SLADCPHRGF GEHDCDHNED AGVVCSETLR LFNGTNSCSG
RVEVYQNGKW GKVCNNNWGK KEASAVCKEL GCGTAKNQQR ASSFGHSLLR GFISRCSNDV
TSFSQCDLEE HVGTCDDATV DCTGNPSIRL VNGTDQCSGR VEILHDGQWG TVCDDEWDIR
DAQVVCKEMN CGTALTVKRS AFFGQGQGEI WLDDVNCMGN ETSLLHCRRP SFGENNCGHG
EDAGLVCSAT IRLLNGTNQC SGRVEANNGG HWAPVYNVNF GMNEAAVVCR EMNCGDPVRV
STAFGQSEDL QGFKISCGGR EGSLTQCSLR DYTRSRNDRI QEVSIECSGN VRLTNGPHPC
AGRVEVYNNG QWGTICGESW DLSDASVVCK QLDCGRAHKI STLTEYGLGS GHAFTHRFEC
NGREQTLSQC SQRSIQGLTC NTTSVAGVAC TASLEARLVN GKDECSGRVE VRSGQTWHTL
CDTDWTQSKA NVVCELLECG NALSAPGGAS FGQGNGTVME ASGSCFDNVT SLKQCSLQGL
RAAATCGHER DAGVSCAASL RLVGGSSQCS GRLEVFYKGQ WGTVCDDDWD MSSADVACKQ
IGCGHAVSAP TGAHFGRGSG PIWLDNVACT GEESAITHCT HNGFGINNCG HGEDASVICL
GSLQKPQITV HPGPEVIWGE KLEITCTVAP EHLGGMFVLK NTQGTFVKEK FSDHEAAAFI
FPSADFSLKG SYFCEYHKKL PNQIIYYPQG NTADISVTVK LEKPSISLTS PHSMVMYSPQ
KISIPKGSSF SITCSTHSRY SSGIFYLRNV NTNTSEEKES FGHSIFYMAY FEFPEVDLKH
QGEYSCIYGI NISSQPFLSL PSKTLQVSVV EITSSSVVAG VVSVLLVLLF LVVVGYLVWR
KKWRGAGVMV QFSKRFGETV KQDQDRSNGG LDQRERTNQL YDRSLPSNSG EDANATAEAD
NVAEKVPEDL AGRVCYELEP LVDSL
//
