ID H2MPW9_ORYLA Unreviewed; 325 AA.
AC H2MPW9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Transmembrane protein 106B {ECO:0000256|ARBA:ARBA00039156};
GN Name=tmem106ba {ECO:0000313|Ensembl:ENSORLP00000020782.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020782.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020782.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020782.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020782.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020782.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004639}; Single-pass type II
CC membrane protein {ECO:0000256|ARBA:ARBA00004639}. Late endosome
CC membrane {ECO:0000256|ARBA:ARBA00037797}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00037797}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00037874}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037874}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the TMEM106 family.
CC {ECO:0000256|ARBA:ARBA00008111}.
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DR AlphaFoldDB; H2MPW9; -.
DR STRING; 8090.ENSORLP00000020782; -.
DR Ensembl; ENSORLT00000020783.2; ENSORLP00000020782.2; ENSORLG00000016598.2.
DR eggNOG; ENOG502QQRZ; Eukaryota.
DR GeneTree; ENSGT00940000158360; -.
DR HOGENOM; CLU_089337_2_0_1; -.
DR InParanoid; H2MPW9; -.
DR OrthoDB; 5353335at2759; -.
DR TreeFam; TF328907; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000016598; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR009790; TMEM106.
DR InterPro; IPR048509; TMEM106_C.
DR InterPro; IPR048511; TMEM106_N.
DR PANTHER; PTHR28556; TRANSMEMBRANE PROTEIN 106B; 1.
DR PANTHER; PTHR28556:SF1; TRANSMEMBRANE PROTEIN 106B; 1.
DR Pfam; PF07092; TMEM106; 1.
DR Pfam; PF21002; TMEM106_N; 1.
DR SUPFAM; SSF117070; LEA14-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..152
FT /note="Transmembrane protein 106 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21002"
FT DOMAIN 175..315
FT /note="Transmembrane protein 106 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07092"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 36055 MW; 455481D53FF8A114 CRC64;
MAAEERATQG TNHRVFSPSS SNEERGGRVY LYSAWCLREN RNKQLRPADG SLFGIKQSQR
TAAMGKAQSH LTKHKGESQD ALTADGECRD GPGEDDGKNG DVSQFPYVEF TGRDSVTCPT
CQGTGRIPRG QENQLVALIP YSDQRLRPSR TKLYVTISVT LCLLLSGLAV FFLFPRSIDV
TYVGVKSAYV SYDQGKRIVY LNITSTLNIT NNNYYSISVT SITAQVQFSK TVIGKAKFNN
VTGIVPLGEQ QLDYTVPTVI ADEMSYMFDY CTLPTIKVHN IVVMMQVTVT TSYFGHTEQV
SQEMYQYVDC GGNTTSLHGN VQVYQ
//