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Database: UniProt
Entry: H2MQA0_ORYLA
LinkDB: H2MQA0_ORYLA
Original site: H2MQA0_ORYLA 
ID   H2MQA0_ORYLA            Unreviewed;       681 AA.
AC   H2MQA0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   31-JUL-2019, entry version 54.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   Name=acvr1 {ECO:0000313|Ensembl:ENSORLP00000020916};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020916, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000020916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020916};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000020916}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020916}, and HNI
RC   {ECO:0000313|Ensembl:ENSORLP00000020916};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSORLP00000020916}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNI {ECO:0000313|Ensembl:ENSORLP00000020916};
RA   Ichikawa K., Yoshimura J., Morishita S.;
RT   "CpG methylation of centromeres and impact of large insertions on
RT   vertebrate speciation.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   RefSeq; XP_011488019.1; XM_011489717.1.
DR   STRING; 8090.ENSORLP00000020916; -.
DR   Ensembl; ENSORLT00000020917; ENSORLP00000020916; ENSORLG00000016722.
DR   GeneID; 101173900; -.
DR   KEGG; ola:101173900; -.
DR   CTD; 90; -.
DR   eggNOG; KOG2052; Eukaryota.
DR   eggNOG; ENOG410XQT0; LUCA.
DR   GeneTree; ENSGT00940000164733; -.
DR   InParanoid; H2MQA0; -.
DR   KO; K04675; -.
DR   OMA; LCNMNIT; -.
DR   TreeFam; TF314724; -.
DR   Proteomes; UP000001038; Chromosome 21.
DR   GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0048185; F:activin binding; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0098821; F:BMP receptor activity; IBA:GO_Central.
DR   GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR   GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
DR   GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; IBA:GO_Central.
DR   GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; IBA:GO_Central.
DR   GO; GO:0032924; P:activin receptor signaling pathway; IEA:GOC.
DR   GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 3.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    681       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017465602.
FT   TRANSMEM    290    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      350    379       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      380    674       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   681 AA;  75243 MW;  71CA3077590D641E CRC64;
     MRSVALFSVL LTLVTPCSSL DGMSGLTNAC LCDEAHCAGS SCFGQLCFAS LSLLSGKPVF
     QKGCIVSKEE EVLRCRKSPA PELVVECCFG HLCNMNISLV PPVKDVEPSA DRPVLRDQEC
     VCEGGVCEQE QRCIGQHCFS SLKVIDGAAG QQKGCLRDDE EGRAVCATPP SPLYAVKCCQ
     GHLCNMNVTV HPPGKEEVLK PVTKEEHECV CEGSSCVTGN RCRGHQCFSS LTDSAGTTVY
     QKGCFKVYEQ STLTCKTPPS RDQIVECCQG HLCNMNITVQ LPPKDHVLSA YSVTTLVTVI
     VAPIIALIFF SALAVFVFRR IHRNQMERLT PRDAEYGTID GLIASNVGES TLADLLDHSC
     TSGSGSGLPF LVQRTVARQI TLNECVGKGR YGEVWRGQWQ GESVAVKIFS SRDEKSWFRE
     TEIYNTVLLR HENILGFIAS DMTSRNSSTQ LWLITHFHEM GSLYDYLQLS TLDAPGCLRM
     ALSIASGLAH LHVEIFGTQG KPAIAHRDLK SKNILVKKNG QCCIADLGLA VMHFQDTNEL
     DVGNNPKVGT KRYMAPEVLD DSIQMDSFES YKRVDIWALG LVLWEIARRT VSNGIVEDYK
     PPFHDVVPSD PSFEDMKKVV CVDQQRPNIP NRWFSDLTLT SMAKLMKECW YQNPSARLTA
     LRIKKTLTKI DNSLDKIKTD I
//
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