ID H2MQC3_ORYLA Unreviewed; 1576 AA.
AC H2MQC3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Intersectin 2a {ECO:0000313|Ensembl:ENSORLP00000020940.2};
GN Name=LOC101165932 {ECO:0000313|Ensembl:ENSORLP00000020940.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000020940.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020940.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020940.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000020940.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020940.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 8090.ENSORLP00000020940; -.
DR Ensembl; ENSORLT00000020941.2; ENSORLP00000020940.2; ENSORLG00000016740.2.
DR eggNOG; KOG1029; Eukaryota.
DR eggNOG; KOG4305; Eukaryota.
DR GeneTree; ENSGT00940000155936; -.
DR HOGENOM; CLU_002819_2_0_1; -.
DR InParanoid; H2MQC3; -.
DR TreeFam; TF324293; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000016740; Expressed in animal zygote and 11 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097708; C:intracellular vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 20..108
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 52..87
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 251..340
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 284..319
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 741..802
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 844..902
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 935..999
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1009..1068
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1091..1277
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1316..1425
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1433..1549
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 216..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 179944 MW; 8AD5DA3A16D7DFEA CRC64;
VSVGFQTALN TIVWAITPEE RGKHDKQFDS LSPILGYVSG EQARKFFLQS GLPASVLAEI
WNLSDLDSDG KMDRLEFSIA MKLIKHRLQG WNLPSSLPTI MKQPPNSNSS GPVPSARFGM
GSMPNLSLSL SSMSTMPIMP SLTPIPANPP LPSMVPLVPM QMTLPLNSSF GNSGLSNGNV
SLLTPPPIPN SAGPPLSGFS SPMAFSPSTG MSKANSLLDL GSSSSNSSST TSLASTSPKM
GAGDWAVPQA SRLKYRQQFN TLDKLMSGYL SGPQVRNALM ASNLTQTQLA TIWYLADVDK
DGQLRADEFI LAMHLVDMAK TGYPLPLTLP QDLVPPSLRG GIKLVELVNG TGPCTTPSLI
DTAETEPSQK VSYEDKLKEN FARGSAELEK RRLALEEEQR KERERRDREE KRAQEQRERE
AREQENRRRL EEERRLERQR EMERQREEER LRELERKEEM ERQRREEYER RMKEELAHRK
EGEREQISRL RAKKRSLELE LEAGKKHKQI SDRLRDAQSK RRIQKAEVDL VNQKRDGRIA
EINTLQLEFE TWQRKLSELV PEQQRLTEKL RKMTSVTSDL CCAALTLTSL TGNVTEKSVN
CRRLKDQLDT LEKETTDKLT QMEQYSKELK EREEEEERQR RLLKEQWARQ REEEEREAQA
RLRAAQEKAQ EEEQQRREEE RRRREEEEER QKREQEEERR RKEVEERQRR EEEERKKREE
EEGRKLKELE VMKKKELERG GQLTTYKALY SFVARNADEL SIDANCLIQV NELTVGEPGW
LCGTYCGKRG WFPQSYAEKC PTFLTSEAAA PAAGKKSCLQ PNTKYEAKVK QFWIFSLKVV
SSCSVTLLAR AISSWSATSG VLLSLSQDDI ITVLQQRDEW WLGQLNGTQG WFPRSYVTLE
MDGSGEYDDP EASRLGASAK KPVFLLLISD LYSVWSTEIA QSVVTAEAPA PHQLLLSPGQ
LIVICAKNST GWWLGELQAR GKKPQRGWFH SSHVKLLGPS STKSSPSPLP VCQVIAMYDY
TAANQDELSF SKGQLINILD KTNPDWWKGE VNGVTGLLPT NYIKMTTESD PSQQWCADLM
TLDTMTPQER KRQGYIHELI QTEETYVEDL ELVLEVFHKP MSESGRLTEA EMATIFVNWR
KLIMCNHKFL KALRARKKTG GENMPIQLIG DVLASELAQM HPYICFCSGQ LNAAALLQSK
TNNQPDFKDF LRKIATNYRC KGMPLSSFLL KPMQRITRYP LLIKNILENT PESHADHGPL
REALERAEEL CFQVNEGVRE KENSDRLEWM QSHIQCEGPI ENLVFNSLTN CLGPRKLLHS
GRLYKTKGTR ELWAFLFNDF LLLTHSTKHF SFSGSDKLFS PKTSAQLKMY KTPLFLNEVL
VKMPPDPSSD EPVFHVSHID RVYTLKTETL SERATWVQKI KAASEHFIET EKKKREKAYQ
ARSLKTSGIG RLLVTIIEAQ ELKACKPNGK SNPYCELTMG AQCYTSRPAS DTPNPKWNFS
CQFFINDLYQ DVLCITVFEK DQFSPDDFLG RTEVPVATIK KDMETKGAAN RRLLLHEVPT
GEVWVKLDLQ LYEPSR
//
