ID H2MQY4_ORYLA Unreviewed; 903 AA.
AC H2MQY4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Rho GTPase activating protein 11A {ECO:0000313|Ensembl:ENSORLP00000021158.2};
GN Name=arhgap11a {ECO:0000313|Ensembl:ENSORLP00000021158.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021158.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000021158.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021158.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000021158.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021158.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2MQY4; -.
DR Ensembl; ENSORLT00000021159.2; ENSORLP00000021158.2; ENSORLG00000016911.2.
DR eggNOG; KOG2710; Eukaryota.
DR GeneTree; ENSGT00940000155312; -.
DR HOGENOM; CLU_010134_1_0_1; -.
DR TreeFam; TF332212; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000016911; Expressed in animal zygote and 13 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04394; RhoGAP-ARHGAP11A; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15670; RHO GTPASE ACTIVATING PROTEIN 11A; 1.
DR PANTHER; PTHR15670:SF4; RHO GTPASE-ACTIVATING PROTEIN 11A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 48..238
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 354..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 98651 MW; 8EBD6F0E9377EAB2 CRC64;
MKVLERNVMR LVAVQELRTA YGIKTKNWNK NKALSTKSTS NQAKVFGVSL DSLPCYNMEC
GSVPGFLVDS CMKLQAHVDT EGLFRKSGSV VRLKALRAKL EVGEECLSSA LPCDVAGLVK
QFFRELPEPV LPTELQDAFL KAQQLPTDQD RTAATMLLTC VLPDKNICVL HYFFDFLRNV
SLRSAENKMN SSNLSVILAP NLLHFGEGAE KMNANTEKRL RLQAAIVQCF IENADNFGVL
PDFLQEKVPA MMGYEGGVLT PTHDSEELDL NFGTKRKHRR SFGVFSSATH VIATPSSKRK
PPLESAHSLG FSNKKRRSVK KNLGLELLSN TLFSGNSTPA SAYSASGVLD SSSSSVLSAG
RSRRQTAASG SRKSKRRSGR NVINRVESGR SGCFSPKVSK KEAPRKSMRL RFSLGKNSKD
SGSKSIGLRL AKQESNTSFH FAEPTEFSPS VYSRKAESQS SKYISRSEDN LLTPKCDPRL
NRTPWSGDTP VGVKAFSEGS FTDTPMRACL KSTYVSEPTV TASKLPAGNN LPMTLCCAAS
AESLDGGSST ETLRQSLSPV LKTVCGQSSA DVQTVELDSD SLPNAPNETS VKALTVAFKT
PNLPSKQSFV ADEQSFTLGQ IEFAALTPLH IDSVVFDSSL HYSPDGGSVV DSLETEREQI
DCSRLIDALD IQSPARFKHH VSSGPQSTPY KPGVETKDDR FPPTRPGFVV SLLHERSGIS
KPVQNQQAVS PQKARVADHI QHFNKLTLYS PPGSKTKQIR SPLKFQRTPV RQTVCRINSL
LGDSRRPRNN AVFGVGQSPR VAKTVSLESG LSPHPQPQQR RPQTRLLNSR TTAKNPPAVP
PKKLATLDRI PKSCALGDVT NKAQQKTKVE SSASTPSEAQ KLLLQQIRLV RPHKINFVTH
SGS
//
