ID H2MRR1_ORYLA Unreviewed; 674 AA.
AC H2MRR1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Fas (TNFRSF6) associated factor 1 {ECO:0000313|Ensembl:ENSORLP00000021443.2};
GN Name=faf1 {ECO:0000313|Ensembl:ENSORLP00000021443.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021443.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000021443.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021443.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000021443.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021443.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004068416.1; XM_004068368.2.
DR AlphaFoldDB; H2MRR1; -.
DR STRING; 8090.ENSORLP00000021443; -.
DR Ensembl; ENSORLT00000021444.2; ENSORLP00000021443.2; ENSORLG00000017140.2.
DR GeneID; 101163241; -.
DR KEGG; ola:101163241; -.
DR CTD; 11124; -.
DR eggNOG; KOG1363; Eukaryota.
DR GeneTree; ENSGT00940000154831; -.
DR HOGENOM; CLU_028119_0_0_1; -.
DR InParanoid; H2MRR1; -.
DR OrthoDB; 8912at2759; -.
DR TreeFam; TF314172; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000017140; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd02990; UAS_FAF1; 1.
DR CDD; cd14413; UBA_FAF1; 1.
DR CDD; cd17129; Ubl1_FAF1; 1.
DR CDD; cd17130; Ubl2_FAF1; 1.
DR CDD; cd01771; UBX_UBXN3A; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR033043; FAF1-like_UBX.
DR InterPro; IPR049483; FAF1_2-like_UAS.
DR InterPro; IPR044541; FAF1_UBA.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR006577; UAS.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR PANTHER; PTHR23322:SF56; FAS-ASSOCIATED FACTOR 1; 1.
DR PANTHER; PTHR23322; FAS-ASSOCIATED PROTEIN; 1.
DR Pfam; PF21021; FAF1; 1.
DR Pfam; PF14555; UBA_4; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00594; UAS; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 3.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS50033; UBX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 124..195
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 593..670
FT /note="UBX"
FT /evidence="ECO:0000259|PROSITE:PS50033"
FT REGION 68..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 75510 MW; DD8AB4F7156AFAE0 CRC64;
MASDSAESNM DREMILADFQ ACTGIDNIAE AITLLELNNW DLVAAINGVI PQENGILQSK
YSSEASQATV FGPPSRSEAA DAAAGGAVPP PSSSSSSSSP PSSSALAYCP VNTSSRHIVE
RQPRMLNFKV EYRQRCVELV LEEGSTVGEI KQILESELGV PVSKMQLKGW KSGDVSDSTV
LKSLHLPKNN SLYVLTPDIA PTASTSKNSA LQESLNQNFL LIISHREAQR DYSLNFPGSR
TIQEVKRNIS DLTNIPVRHQ QWEGWPASAS DDSMTLALSG ISYPCHHLSV CRRSSPANMQ
EPTEESADVH MISDSEGDDF EDASEFGVDD TEMFGMGSST CRKSPMMPEN SENEADALLH
FTAEFSSRYG ETHPMFFIGS LEAASQEAFY GKARDRKLLA IYLHNDDSVL SNVFCSQMMC
ADSIVSYLSQ NFITWAWDVT KEANKARLLT MCTRHFGSVV TQTIRTYNTD QFPLLLIVMG
KRTSNEVLNV IQGNTTVDEL MMRLMAAMEI FTAQQQEDIK DEDEREARET VKREQDEAYR
LSLEADRKKR EAQEREEAEQ VRLEQMRKEQ EEEKEAIRLS LEQALPPEPD EESGEQISKL
RIRTPSGEFL ERRFLSSCKL QVLFDFVASK GYPFEEFKLL TTFPRRNITQ LEPGSTLMEA
KLFPQETLFL EAKE
//
