ID H2MS55_ORYLA Unreviewed; 1274 AA.
AC H2MS55;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSORLP00000021591.2};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSORLP00000021591.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000021591.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000021591.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021591.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000021591.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000021591.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2MS55; -.
DR Ensembl; ENSORLT00000021592.2; ENSORLP00000021591.2; ENSORLG00000017258.2.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_1_0_1; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000017258; Expressed in bone element and 15 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 331..518
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 140676 MW; 937A4A6B88FE76E8 CRC64;
GEPFDFDDDE MPEPPPTSQD RSKDGGVAAP PVPSTAPSPA DSSVAESDPH PPPASHGSSP
QGKVNPYSVI DIAPIPPPLH QLQNGSPGLT SGYSVPVPCG YATPSGVPLI TPAYTTPVII
RHLSVDEDGK VDVFSEEYPP ITEEDALAKW VSDPANTAWM ESKDGFSYPD EMIYDDVEFG
EEGGCSSSPD NGWSSSEFES YDEASEGEGG PENGLPNLSQ DLTRLKEHYE KKMKELMANT
VGTVELQQLK QKHEQKMQKL VKAAKDGTKD GLEKTKAAVK KGRSFIQTKS FCHGNEDSSH
EESELFIEVD CFNVEPVLCP APEGLSQQQL VRRCILESIL ESEKNYLNAL KRILEHYEKP
LSQIEPRLLS DRKLKMIFYR VREILQCHFL FQIALASRVA EWDGLEMIGD VFVASFCKSM
VLDAYSEYVN NFSTAMAVVR KTCISKPGFL DFLKHRQETS SDRMTLYGLM MKPIQRFPQF
ILLLQDMLKN TPVGHADRLP LQMALTELET LAEKLNEKKR EADQRCEIRH ISKAMNERYL
NKLLSHGSRY LIRSDDMVET VYSERGEILK TKERRLFLLN DVLMCATPNL RGSGSVPLNQ
KFLLKWSVPL SLVEVLEFGS SEDAVGGGGR LLAPHSGEKV VINAKPNKLY MGPGQLYQDL
QNLIHDLSLV HQISSMISSL KGNYQNVNST VAQDWVSGLQ RLILKKEEEI RAADRCRIQL
QLPGKQDKTG RPTYFSAVFN THSPAIKQSW ISNLQMAKLA LGTVHMGLCF PYWGWFFAED
DGNQIKKQKH PLLLRQIPVI MSKLQEFKIE CAVHNPEPFI NTESTADRPA MGHGCVWVAS
CTNQMGQIAI VAMQNSSPKV TECFNVESRI LCMAYVPAEQ IQENDGDDNR ATARDAPSVC
LGMEEGSIIV YRSSQRSKKV RLQHFFTPEK STVTSLVYRK QSLFVGLVSG SVAVYSRSPD
SLWDYEKPKL LKLGVLPVKA MLAVEEHLWA SSGGQVFIIC THTHCIQRHL EAHQEEGMVV
SHMVAAGVGI WIAFSSGSTL RLFHTETLEH LQDINIATPV HSLLPGNQRV LVSSLLVCHG
LLLVGTNLGV TVALSVPRLQ GIPKVTGRGM VSLHAHNGPV KFLVMATAVC NHLPDVLSPS
PPSLPQPSEP QDVDGDRPPS DSATPSSQGH GVWLGEAGCT AMALQDSLSS SSCGSLAPSQ
GSLEHGPEDG ALYDTIHDAA HHQRARRSSK VDVSSLLVVS GGLGHRRVTK KTKPSRHEDN
TSTIMIWQIP LLSM
//
