ID H2MTN0_ORYLA Unreviewed; 316 AA.
AC H2MTN0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=NF-kappa-B inhibitor alpha {ECO:0000256|ARBA:ARBA00041123};
DE AltName: Full=I-kappa-B-alpha {ECO:0000256|ARBA:ARBA00041987};
GN Name=nfkbiab {ECO:0000313|Ensembl:ENSORLP00000022136.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000022136.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000022136.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022136.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000022136.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022136.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC {ECO:0000256|ARBA:ARBA00038439}.
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DR RefSeq; XP_004082709.1; XM_004082661.2.
DR AlphaFoldDB; H2MTN0; -.
DR STRING; 8090.ENSORLP00000022136; -.
DR Ensembl; ENSORLT00000022137.2; ENSORLP00000022136.1; ENSORLG00000017687.2.
DR GeneID; 101168165; -.
DR KEGG; ola:101168165; -.
DR CTD; 323099; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163080; -.
DR HOGENOM; CLU_000134_6_3_1; -.
DR InParanoid; H2MTN0; -.
DR OMA; TYGLDNC; -.
DR OrthoDB; 621606at2759; -.
DR TreeFam; TF320166; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000017687; Expressed in pharyngeal gill and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR PANTHER; PTHR46680:SF1; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 116..148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 222..254
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..306
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 35591 MW; 59B67546FBD80FEE CRC64;
MDLHRNTVLN QMDYSEDPKE VKSSQLTEDR LDSGIDSLKE EEYQAVAAEI HRLQLDCEHK
QPAAVTGEPL QEWQTQITEE GDTLLHLAII HEAKDFTQKM INMTKNTDFL NAQNDLRQTP
LHLAVITNQP DVCYGLIVSG CNITVVDNNG DTPLHIACRH GNLHCFSAIT QNCRPEQLHT
AMATWNYNGQ NCLHLASIYG FLLLVEKMVD LGADINTREQ HNGRGALHLA VDQQNLCLVK
LLLKKGADPN LLTSGGYTPY HLTYGLDNCD IRKELHPLTH PDLRELPDSD SENSEEDSDE
EFDEGVMYDD IKLNGH
//
