ID H2MTX8_ORYLA Unreviewed; 1091 AA.
AC H2MTX8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=LOC101168002 {ECO:0000313|Ensembl:ENSORLP00000022237.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000022237.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000022237.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022237.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000022237.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022237.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004081994.1; XM_004081946.2.
DR AlphaFoldDB; H2MTX8; -.
DR Ensembl; ENSORLT00000022238.2; ENSORLP00000022237.2; ENSORLG00000017764.2.
DR GeneID; 101168002; -.
DR KEGG; ola:101168002; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156894; -.
DR HOGENOM; CLU_006480_1_1_1; -.
DR InParanoid; H2MTX8; -.
DR OrthoDB; 4259465at2759; -.
DR TreeFam; TF352008; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000017764; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF41; PROTOCADHERIN-17; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1091
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017457072"
FT DOMAIN 17..123
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 124..234
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 235..342
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 344..448
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 449..558
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 564..658
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 847..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 119668 MW; 0C8B084287D5B5C4 CRC64;
MRLSVPIFFL LWVKALSLKN LNYSVPEEQG PGTVIGNIAK DAGYGTIERG KKSNFRVLEN
SAPHLVDVDP ESGLIFTKQR IDRETLCRRN PKCQLSMEVF ANDKEICMIK IDIQDINDNS
PSFPSDHVNI DISENAAAGT RFPLTIAHDL DSGENGIKTY QVTRDDYNTF SLDLKVRGDG
TIYPELVVQR PLDREDQSHH TLLLTAIDGG EYPRSGSMQI NVRVTDSNDN SPVFEKSSYV
IEIPENLPPG KILIDLNATD QDEGSNGQVV YSFTGYASER IQDLFSIDPN TGVIKVQGEI
DFEENPIIEF DVQAKDLGPN PIPGHCKITV KVQDKNDNSP VITFVSVRQG AISEAAPPDS
VIALVRVTDK DSGRNGQLQC RVLGNVPFRL QENNDNFYTL LTDRPLDRET RDEYNVTIVA
RDNGIPSLNN TRSFTVKILD ENDNAPRFTK SLYVLQVPEN NIPGEYLGSI LAHDPDVGRN
GTVTYSILPS HIGDVSVYTY VSVNPTNGAI YASRSFNYEQ TKSFEFKVQA KDGGSPHMES
TSTVRVNILD VNDNLPVIIL PLLQNDTAEI PVPRNVGIGY IVATVKAVDH DHGDSGHLTY
EITEGNDDHL FEIDPVGGEV RTAHALWEEI APVVELVVRV TDHGKPPLSA VAKLIIKVNT
ETAVGGGSSA SGEKQHWDVS LPLIVILCII SVMLLAVMTA IAVKSKHHDK ESGNYNCRMA
EYSNTPVGKG KKKRINKSDI MLVQSEMEER DSASRMNVVS SPSLITSPIC FDYQSPLPLT
LPRSEVMYLK TTSNSLTVPR SGCHSSFAGL SSDTSGNRMS VIQTENFSSE PNYSGSRQPF
VQSSTFKDAE RASLRDSGHG DSDQADSDQD TNKGSHCDTS AKEALKMKAV AVNGQPFDKE
QDKSVHCTDE CRALGHSDRC WMPKLRVGSQ ADSADNRTNL FIPVGMDAMV ETEIYGTISC
NSRKTLSTFG KEQRDSTILV ANVKPYLKSQ RALSPPLQES PSASSSPTKS STPMDLANQE
SKEERDRGSD SSAYGPPDGQ CSPQHTELEE PSYLTCELRP KSLSSSLIHS SVISQECGGS
DRTLNPRDSG N
//
