ID H2MTY5_ORYLA Unreviewed; 1021 AA.
AC H2MTY5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=si:ch211-199f5.1 {ECO:0000313|Ensembl:ENSORLP00000022244.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000022244.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000022244.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022244.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000022244.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022244.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004081830.1; XM_004081782.2.
DR AlphaFoldDB; H2MTY5; -.
DR Ensembl; ENSORLT00000022245.2; ENSORLP00000022244.2; ENSORLG00000017770.2.
DR GeneID; 101167407; -.
DR KEGG; ola:101167407; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000155219; -.
DR HOGENOM; CLU_006480_1_2_1; -.
DR InParanoid; H2MTY5; -.
DR OrthoDB; 4259465at2759; -.
DR TreeFam; TF352008; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000017770; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF46; PROTOCADHERIN-8; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..181
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 182..290
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 291..398
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 405..509
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 510..625
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 625..729
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 812..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112569 MW; 37C59C62561C735B CRC64;
MRARSNFHFT TVQFIKRELR REPAADVKAC LAHKEAARRG KISRKMTKGT LLTCWVFIFS
LHQFLFTSWA RSEGNTVRLQ TREEEPPGTV IGNLAKDMSL SLSHSSKSNF RMMKQFNDSF
IRVRESDGEL SVGERIDRER ICRHTPQCLI TFDVVNFSKD RYKLIHVEVE IKDINDNSPE
FPSKEYMVEI SENAALGSRI PLDPAVDADV GSNYIQSYQI SVNSHFTIDV LLRADGVKYA
ELVLMKELDR ETQSFYNVEL VATDGGNPYR SGSSKITVKV TDFNDNSPVF DQNSFSVSLP
EDAPPGTVIL DLNAVDADEG LNGEVVYGFG KQVSHEIREL FQVDSKSGHL TLRSPVDFED
KSTYEVDVQA TDLGPNPTPS VCKIIIHVTD VNDNAPEISI TPMTSITTGV AHISEAADRD
SLVALISTMD RDSGINSQVH CTLYGHDHFK LRQAHEDSYM IVTAAALDRE RIREYNLTVM
AEDFGSPPLR KITQFTIRLN DENDNAPHFA KAVYEVPVVE NNAPGAYITT VEASDADLGN
NGKITYRLVE GVIMGSPVNT FVSLNSMSGS IYALRSFNYE VMKQLDIHVQ ASDGGSPQLQ
STAIIRLKIV DQNDNQPAII EPPLFKGSAE VFLPKDAPAG YVVTQIKATD ADEGTNAQLS
YKIAEGGHLG FSIHKDTGKV HVSRQLAYDP TDMVKIIISV SDHGSPSLTS TAALILSFIE
GTIPSLPSLA EEGNEEGFEW DTSVAIIIVL AGSCSLLLLA IILITTICSR RKKEAKEGRF
DEKENAANVE KVESGHIDSL IANHNGKAFD SHQFSEDPSL ANSNTAGSGC EDDKQTSGMF
EPNNRMEGKL KGYSTLPGYG KETVRPITIW KGNSFTTISA REPHFSGKDS GKGDSDFNDS
DSDISGDVHK KESPPINSLW ACTNECKVLG HSDRCWSPSA TRPNTSMACG PHLSTFSKTA
TLPRDARREN YYPALLPKTS GLQSVYEKVQ HQEFDYILVG PPTPARIQET DEISIPEYTN
S
//
