ID H2MVM1_ORYLA Unreviewed; 1166 AA.
AC H2MVM1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Myosin IB {ECO:0000313|Ensembl:ENSORLP00000022863.2};
GN Name=MYO1B {ECO:0000313|Ensembl:ENSORLP00000022863.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000022863.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000022863.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022863.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000022863.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000022863.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; H2MVM1; -.
DR STRING; 8090.ENSORLP00000022863; -.
DR Ensembl; ENSORLT00000022864.2; ENSORLP00000022863.2; ENSORLG00000018254.2.
DR GeneTree; ENSGT00940000155752; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; H2MVM1; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000018254; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005903; C:brush border; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF802; UNCONVENTIONAL MYOSIN-IB ISOFORM X1; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 7.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 12..698
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 978..1164
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 575..597
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 105..112
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1166 AA; 134932 MW; 2D97332F1D81DE74 CRC64;
MEGKASLLDN MIGVGDMVLL EPLSEDSFLE NLKKRFDHNE IYTYIGSVVI SMNPYRSLPI
YTPEKVEEYR NRNFYELSPH IYALADEAYR SLRDQDKDQC ILITGESGAG KTEASKLVMS
YVAAVCGKGQ EVNKVKEQLL QSNPVLEAFG NAKTVRNDNS SRFGKYMDIE FDFKGDPLGG
VISNYLLEKS RVVKQPRGER NFHVFYQLLS GASDETLKKL KLDRDVSKYN YLCLDSASVS
GVDDAANFRT VRNAMQIVGF MEDEVQSVLQ LVAAVLKLGN IEFKPESRSN GLDESRVKDK
NDLKEMCELL GIEQSVLERA FSYRTVEAKS EKVSTTLNVA QAYYARDALA KNLYSRLFSW
LVTRINGSIK AQAKTRHKVM GVLDIYGFEI FEDNSFEQFI INYCNEKLQQ IFIELTLREE
QEEYIREGIE WTNIEYFNNA VICDLMENNQ NGILAMLDEE CLRPGTVTDE TFLDKLNTIC
AEHQHFESRL SKNSKFLTDH SLPHNCFRIQ HYAGKVLYRV EGFVDKNNDL LYRDLSQAMY
KANHNLIKQL FPEGSPAKIN LKRPPTAGFQ FKASVGTLMR NLQTKNPNYI RCIKPNDKKA
SHIFTESLVC HQVRYLGLME NVRVRRAGYA FRQAYEPCLE RYKMLCKKTW PHWKGPARQG
VEVLMADLKV PAEEYSYGRS KIFIRNPRTL FFLEERRRQC LQDLAALIQK IYRGWKCRRQ
FLLMKKSQVV VAAWYRRYAQ EKKYKKIKRA TTVMQSYARG WQARKLLRQL KHQKRCEEAA
TTIAAYWHGT QARMELRRLK EEVRNKHAVT VIWAYWQGTK ARTELRQLKE EARNKHAVSV
IWAGWQGTKA RRELRRLKEE ARRKHAVAVI WAYWQGLKVR REYRKFFRAN AGKKIYNFTV
QRIIQKYFLN LRKNLPSMSP IDKSWPTRPY SFLDGVHTEL RRIFHLWRCK KYRSQFTEEK
KAVYEEKLEA SKLFKDRKAL YPSSVSQSFK GDYLEINKNP KYQKLHSAVD EKVLLADTIS
KINRANGKGT PRIFLLTKKS VVLADQKTGQ VKASVPLLDL ASVSVSKQSD GFFALKLKEG
SASAVKGDFL LSSERLIEII TKLYRLSAAN AERVPLSVDI SDEFLVQFKT DKVCVKFIQG
SPRNGNSASC KRKNNRLLEV SVPSTP
//
