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Database: UniProt
Entry: H2MZ79_ORYLA
LinkDB: H2MZ79_ORYLA
Original site: H2MZ79_ORYLA 
ID   H2MZ79_ORYLA            Unreviewed;      1804 AA.
AC   H2MZ79;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 47.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSORLP00000024363};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024363, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000024363}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024363};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   STRING; 8090.ENSORLP00000024363; -.
DR   Ensembl; ENSORLT00000024364; ENSORLP00000024363; ENSORLG00000019583.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001038; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    227    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    399    426       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    605    632       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    644    667       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    724    752       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    814    837       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1055   1073       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1094   1116       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1122   1142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1171   1197       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1296   1320       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1379   1397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1409   1427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1459       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1496   1524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1596   1622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1639   1674       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       21     48       {ECO:0000256|SAM:Coils}.
FT   COILED      423    457       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1804 AA;  206170 MW;  ECDCD14AAC77137E CRC64;
     MTSLLPPLGA EVFIRFTPAS LEKIQQRHEA EEEELQRKKD KNIEIAEDDL PKPASHLEAG
     KPLPFIFGDP PPEFLNIPLE DLDPFYGSQK TFIVLSKGNI IYRFNAEPAC YVLTPFNPLR
     IFSIRILIHS QTLFSLFIML TILTNCVFMT MSDPPAWSKT VEYLFTGIYT FEAIVKVLSR
     GFCIGNFTFL RDPWNWLDFM VISMAYLTEF VDLGNVSALR TFRVLRALKT ITVIPGLKTI
     VGALIQSVKK LGDVMVLTVF CLSVFALIGL QLFMGNLRQK CVLMPSDFSS SSDGFNSSFY
     DNDTNGDNST GFDYHEHINN PDNYYYLPGQ ADALLCGNSS DAGLCPDGYT CLKAGRNPNY
     GYTSYDSFSW AFLSLFRLMT QDFWENLFQL TLRAAGKTYM IFFVVVIFLG SFYLINLILA
     VVAMAYAEQN EATMAEAKQK EEEYAQILEA LKRRDEEVLK QVTCKMSLLQ KQNSDPQRKD
     TVEESKSTEQ ENVAVDGCDS SAFFAYSVRI GNMSEYKASC YALRRAVRAA KHRYRERIES
     HFQLNDSRQA NSSSSSPTSV LSVPTVFHPY SYEDDQRPCP LCWYKFSDIF LKWNCCGCWR
     WLKQLLYTIV MDPFVDLTIT ICIVLNTVFM AMEHYPMTEN FEELLSIGNL VFTGIFTAEM
     VLKLLALDPY YYFQVGWNIF DSIIVTMSLV ELGLADVEGL SVLRSFRLMR VFKLAKSWPT
     LNMLIKIIGN SIGALGNLTL VLAIIVFIFA VVGMQLFGKN YKDCVCLIAE DCKLPRWHMN
     DFFHAFLIIF RILCGEWIET MWDCMEVAGQ TMCLIVYMMV LVIGNLVVLN LFLALLLSSF
     SGDNLSATEE EGENNLQIAI NRINRAISWT KIWILKRTDS FVQKKTHITE QSCAGDVDED
     RNNEALALTF VSSGLSAPQV KDARDYQSNI TSNYHNITSL KVPIAESESD LEIPANEDEE
     EEEEEKCLSE VKSCQFFVIR HEQQKTCEES SVCSTIEETV VVEVETYEDT NIPEDCCTDK
     CYSRCPCLYI DTSHGRGKVW YIFRRTCFSI VEHNYFETFI IFMILMSSGA LAFEDIYMEQ
     RRVIKTILEY ADQVFTYVFV VEMLLKWVAY GFTTYFTNAW CWLDFLIVDV SLVSLTANIL
     GYSELGAIKS LRTLRALRPL RALSRFEGMK VVVNALVGAI PSIFNVLLVC LIFWLIFSIM
     GVNLFAGKFY YCFNETSQEI FQPGAINNKT ECLALIHENL TDVRWKNVKI NYDNVGMGYL
     SLLQVATFKG WMDIMYAAVD SREVESQPMY EENLYMYIYF VCFIIFGSFF TLNLFIGVII
     DNFNQQKSKL GGTDIFMTEE QKKYYNAMKK MGSKKPQKPV PRPENHFQGL VFDLVTKQFF
     DIFIMVLICL NMVTMMVETD DQTLEKEIIL YWVNLVFIVI FTTECSLKII ALRQHYFAVG
     WNIFDFVVVI LSIVGLLLAD IIEKYFVSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL
     MMSLPALFNI GLLLFLVMFI FSIFGMSNFA YVKKEVMIDD IFNFETFGNS MICLFMITTS
     AGWDGLLSPI MNTPPDCDPN FENPGSLVRG NCGSPAVGIV FFTSYIIMSF LVVVNMYIAI
     ILENFNVATE ESSEPLSEDD FEMFYETWEK FDRDASQFIH YNELSAFCDV LQDPLRIPKP
     NNIKLVTMDL PLVPGDKIHC LDILVALIKE VLGDSGAIET LKASLEEKFM ANNPSKVSYE
     PISSTLRRKQ EEVAAVTIQR AYRRHLQKRS VKLASWKIKD KTQNELSPQE EDGLLSKETS
     QYLG
//
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