ID H2MZH2_ORYLA Unreviewed; 1291 AA.
AC H2MZH2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Rho GTPase-activating protein 29 {ECO:0000256|ARBA:ARBA00040783};
DE AltName: Full=Rho-type GTPase-activating protein 29 {ECO:0000256|ARBA:ARBA00042921};
GN Name=LOC101172644 {ECO:0000313|Ensembl:ENSORLP00000024476.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024476.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000024476.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024476.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000024476.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024476.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8090.ENSORLP00000024476; -.
DR Ensembl; ENSORLT00000024477.2; ENSORLP00000024476.2; ENSORLG00000019692.2.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR HOGENOM; CLU_006236_0_1_1; -.
DR InParanoid; H2MZH2; -.
DR OrthoDB; 5395569at2759; -.
DR TreeFam; TF351450; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000019692; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20816; C1_GMIP-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF7; RHO GTPASE-ACTIVATING PROTEIN 29; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 220..483
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 667..712
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 726..940
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1231
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 141921 MW; 79BA4A72674C7A80 CRC64;
MISRSRSASS AGGSPGSAAS EARSVGSTRT WAAGGGGRNP NPHYSMGASS LLTGAPGLDP
DYVMQLVSDV RGFAGILVSL KGAFQHEENM KDLQELVQER LAELFRALKA VIGKHRTLNS
VDVLGAAGTV MAKVKGVKFS EVTFEDQSAV FREIHAAIDT LAFTFGNVVS DFLMGDVDRA
SGLGGPQTRR SRSFDDLSAD PDRHHKRDGG GPDLQLSREE EVDLTLLRNE VGVESALLYA
KAWSKHIKDL LVWMEKRVSM DIEYAKNYSK IAESAKALAS QQDFMPFSDI YISTFKKDIE
HNTLLLQTAL ALQSNKFIQP LLARKNELDK LRKELKEQWQ REQRKMHEAN AALRKAQTLA
EQRQEEYKKV LSSSSRSQEE QGNPGNKQLD RRRRLEEEAL QKAEEAQDQY QSCRADAGVR
RMDLANAKRT VLTQLRETIF QCDLTLKAVT VNWLQIQQAQ TVVAPTHYQA LNENAKLYEP
GECYAEFVRN LPRNLPKEHL HSVSCEGSRF GFNKRFLSSS HSSQGNLSQT STTVCDEGDL
LHPQPVKMGG ERSSSSTDLP DVSAASRNQA QRKAWASGSQ VSQGGVCSDS ESAGGSSESR
SIDSPTASPG DLRRRLPRTP STGTMSSADD LDDREPLSPL DNGPAELVTS SSPGPFRNAQ
MSKAAQTHRL RKLRAPSKCR ECDGLVVFHG AECEECSLAC HKKCLETLAI QCGHRKLPGK
LQLFGVDFAL AAKNCPDGIP FIIRKCASEI ESRALNVKGI YRVNGAKSRV EKLCQAFENG
KDLVELSEHS PHDISNVLKL YLRQLPEPLI LHRFYNDFIG LAKESQRASK EGGGRNQKGQ
HAGKGPGPHM KKVFSRVREL LNQLPVSNFR TLCFLTAHLN RVAEHAEENK MTVSNLGIIF
GPTLVKPQQT DAEVSLSSLV DYPYQVLMVE LLVRHFHLVF DNPPLQGSET ARNSPRLTPQ
QKVRQLSKHS TSLTDIKENP KVFKRFSSVI PSTHILDEVQ EVEPGKDQTE VSGQSNEGPT
SPGGDVQRSA LMFQGPPSTA VQQKIQLRPQ RGWQASRPIS MPLARNHRNV TGEGCERDAP
PVSIQEEPEP ERVRPCTSSR VSSYYISPFI DTQTMPRKTW DRKYKHYDVT PRTAMIIANL
PPPHSGTQPI TTALSAGRGG AAASETPPSP VVPFSVAKRD SPSPMLTLRA PRTLQPPPGT
FYKPLPSSTL LNGGAPVAPP TSPPHPEPSL PLTSATAPVS PKQAPLPTHV SSDGASPPPP
APSSPSDCKP VQQRLRPRRL QELEHRESHF V
//
